Mild systemic hypoxia and photopic visual field sensitivity

Acta Ophthalmologica
B FeiglIan Stewart

Abstract

Flickering stimuli increase the metabolic demand of the retina, making it a sensitive perimetric stimulus to the early onset of retinal disease. We determine whether flickering stimuli are a sensitive indicator of vision deficits resulting from acute, mild systemic hypoxia when compared to standard static perimetry. Static and flicker visual perimetry were performed in 14 healthy young participants while breathing 12% oxygen (hypoxia) under photopic illumination. The hypoxia visual field data were compared with the field data measured during normoxia. Absolute sensitivities (in dB) were analysed in seven concentric rings at 1°, 3°, 6°, 10°, 15°, 22° and 30° eccentricities as well as mean defect (MD) and pattern defect (PD) were calculated. Preliminary data are reported for mesopic light levels. Under photopic illumination, flicker and static visual field sensitivities at all eccentricities were not significantly different between hypoxia and normoxia conditions. The mean defect and pattern defect were not significantly different for either test between the two oxygenation conditions. Although flicker stimulation increases cellular metabolism, flicker photopic visual field impairment is not detected during mild hypoxia. These fi...Continue Reading

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Citations

Apr 12, 2012·Acta Ophthalmologica·Helin Deniz DemirIlker Etikan
Sep 19, 2014·The British Journal of Ophthalmology·A M ShahidiJ G Flanagan
Oct 2, 2014·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Nicola PescosolidoDario Di Blasio

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