Mild traumatic brain injury recovery: a growth curve modelling analysis over 2 years.

Journal of Neurology
Ellen L CarrollVirginia F J Newcombe

Abstract

An improved understanding of the trajectory of recovery after mild traumatic brain injury is important to be able to understand individual patient outcomes, for longitudinal patient care and to aid the design of clinical trials. To explore changes in health, well-being and cognition over the 2 years following mTBI using latent growth curve (LGC) modelling. Sixty-one adults with mTBI presenting to a UK Major Trauma Centre completed comprehensive longitudinal assessment at up to five time points after injury: 2 weeks, 3 months, 6 months, 1 year and 2 years. Persisting problems were seen with neurological symptoms, cognitive issues and poor quality of life measures including 28% reporting incomplete recovery on the Glasgow Outcome Score Extended at 2 years. Harmful drinking, depression, psychological distress, disability, episodic memory and working memory did not improve significantly over the 2 years following injury. For other measures, including the Rivermead Post-Concussion Symptoms and Quality of Life after Brain Injury (QOLIBRI), LGC analysis revealed significant improvement over time with recovery tending to plateau at 3-6 months. Significant impairment may persist as late as 2 years after mTBI despite some recovery over t...Continue Reading

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Citations

Jun 16, 2021·The Journal of Clinical Investigation·Marie HanscomTerez Shea-Donohue

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

SPSS Statistics

Related Concepts

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Brain Injury & Trauma

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