Mild White Matter Changes in Un-medicated Obsessive-Compulsive Disorder Patients and Their Unaffected Siblings

Frontiers in Neuroscience
Siyan FanPetra J W Pouwels

Abstract

Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disorder with moderate genetic influences and white matter abnormalities in frontal-striatal and limbic regions. Inconsistencies in reported white matter results from diffusion tensor imaging (DTI) studies can be explained, at least partly, by medication use and between-group differences in disease profile and stage. We used a family design aiming to establish whether white matter abnormalities, if present in un-medicated OCD patients, also exist in their unaffected siblings. Forty-four OCD patients, un-medicated for at least the past 4 weeks, 15 of their unaffected siblings, and 37 healthy controls (HC) underwent DTI using a 3-Tesla MRI-scanner. Data analysis was done using tract-based spatial statistics (TBSS). Fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) values were compared within seven skeletonised regions of interest (ROIs), i.e., corpus callosum, bilateral cingulum bundle, bilateral inferior longitudinal fasciculus/frontal-occipital fasciculus (ILF/FOF) and bilateral superior longitudinal fasciculus (SLF). Un-medicated OCD patients, compared with HC, had significantly lower FA in the left cingulum bu...Continue Reading

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Citations

Nov 20, 2016·Human Brain Mapping·Wang-Tso LeeSteven Shinn-Forng Peng
Apr 17, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Maria Paula MazieroMarcelo Q Hoexter
Feb 12, 2021·Journal of Behavioral Addictions·Małgorzata DrapsMateusz Gola

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Software Mentioned

FMRIB Library
FNIRT
TBSS
FSL
Randomise

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