Miliary metastases are associated with epidermal growth factor receptor mutations in non-small cell lung cancer: a population-based study

Acta Oncologica
Fred HsuAlex De Caluwe

Abstract

Miliary metastases are characterized by metastatic nodules that are diffuse, innumerable and small. The purpose of this study was to examine the incidence, prognostic significance and impact of epidermal growth factor receptor (EGFR) mutations for miliary metastases from non-small cell lung cancer (NSCLC). Patients were identified from a Provincial cancer registry (British Columbia, Canada) for the period 2010-2012. Inclusion criteria were stage IV NSCLC at presentation and conclusive EGFR mutation testing. Miliary metastases were defined by subjective and objective radiographic criteria. The primary endpoint was the incidence of miliary lung, brain and liver metastases. Secondary endpoints were survival and the prognostic implication for each site of miliary metastases. For 543 patients, the total number of brain, lung and liver metastases were 165 (30.4%), 290 (53.4%) and 67 (12.3%), respectively. The EGFR mutation positive (EGFR+) subgroup had a significantly higher 3-year cumulative incidence of miliary brain (4.1 vs. 0.5%, p = .015) and miliary lung (11.6 vs. 3.3%, p < .001) metastases compared to EGFR wild type (WT). A greater proportion of metastases from EGFR + cancers were miliary for brain (8.5 vs. 1.7%, p = .035) and...Continue Reading

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Citations

Jun 27, 2019·QJM : Monthly Journal of the Association of Physicians·Shu-Zhong LiuYong Liu
Dec 31, 2019·AJR. American Journal of Roentgenology·Dexter P MendozaSubba R Digumarthy
May 27, 2020·Molecular and Clinical Oncology·Ryota OtoshiOgura Takashi
Sep 22, 2019·Cancers·Subba R DigumarthyLecia V Sequist
Apr 28, 2020·ACG Case Reports Journal·Charles A LavenderRagesh B Thandassery
Aug 5, 2020·British Journal of Cancer·Matthew N Mills, Kamran A Ahmed
Mar 24, 2021·Thoracic Cancer·Momoko MorishitaHaruhito Sugiyama

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