PMID: 9542612May 23, 1998Paper

Milk hypersensitivity--key to poorly defined gastrointestinal symptoms in adults

Allergy
L PeltoE Isolauri

Abstract

Lactose intolerance is a common adverse reaction to milk in adults, while milk hypersensitivity is a disorder of infancy. We hypothesized that milk hypersensitivity may cause many unspecific gastrointestinal disorders in adults. Twenty adults were subjected to double-blind, placebo-controlled milk challenge. Phagocyte activity, and Fc gamma and complement receptor expression of phagocytes were assayed, and serum total IgE, milk-specific IgE, and serum reactivity to milk protein were determined. The challenge increased phagocyte activity and complement receptor expression of phagocytes in subjects designated milk-hypersensitive, who had gastrointestinal symptoms from milk ingestion but normal lactose tolerance. The increase was not detected in lactose-intolerant or control subjects. The milk-hypersensitive group was also distinguished from the lactose-intolerant group by enhanced serum reactivity to milk protein. Only two out of nine milk-hypersensitive subjects had detectable milk-specific serum IgE. It is concluded that milk hypersensitivity in adults, occurring as gastrointestinal reactions, may be more common than previously thought.

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Citations

Apr 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·J KokkonenE Savilahti
Nov 1, 1997·Environmental Toxicology and Pharmacology·E Isolauri
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L PeltoS Salminen
May 25, 2007·European Journal of Clinical Nutrition·S SeppänenR Korpela
Sep 10, 1999·Annals of Medicine·E IsolauriT Mattila-Sandholm
May 20, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L MattilaK Kalimo
Apr 2, 2016·The Journal of Dairy Research·Anu TurpeinenEveliina Myllyluoma
Dec 1, 2011·Probiotics and Antimicrobial Proteins·Umesh Kr ShandilyaV K Kansal
Mar 22, 2006·The Journal of Nutrition·Dennis A SavaianoGeorge P McCabe
Feb 7, 2001·Pediatrics·A PatjaH Peltola

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