PMID: 7579Jul 1, 1976

Milk lipoprotein lipases: a review

Journal of Dairy Science
P G Jensen, R E Pitas

Abstract

Lipoprotein lipase activity has been found in the milks from severals species where it is assumed to result from leakage from the mammary gland into milk. The function of the enzyme in the gland is apparently to assist in the transfer of blood lipoprotein triacylglycerol fatty acids into milk triacylglycerols. Bovine skim milk is one of the richest sources of lipoprotein lipase and this enzyme has been purified extensively (7000 fold) by affinity chromatography. The lipase has a molecular weight of about 62000, is inhibited by protamine sulfate, 1.0 M sodium chloride, apolipoprotein C-I (apolipoprotein-serine), and apolipoprotein C-III (apolipoprotein-alanine). The enzyme is activated by apolipoprotein C-II (apolipoprotein-glutamic acid), serum, and by heparin to which it also binds. The lipase is highly specific for the primary esters of acylglycerols and exhibits a slight stereospecificity for the sn-1 ester in preference to the sn-3-ester. Bovine milk also has separate activity toward 1-monoacylglycerols. Human milk contains a serum stimulated lipoprotein lipase with many of the characteristics of the enzyme in bovine milk, as well as an enzyme stimulated by bile salts which resembles the sterol ester hydrolase of rat pancre...Continue Reading

References

Jan 1, 1975·Annual Review of Biochemistry·J D MorrisettA M Gotto
Aug 18, 1975·Biochemical and Biophysical Research Communications·A M Ostlund-Lindqvist, P H Iverius
May 1, 1975·The American Journal of Physiology·M M Garrison, R O Scow
Nov 18, 1974·Biochimica Et Biophysica Acta·O Hernell, T Olivecrona
Sep 1, 1973·Journal of Dairy Science·R S Emery
Mar 1, 1974·The American Journal of Physiology·O ZinderR O Scow
May 23, 1972·Biochimica Et Biophysica Acta·P Nilsson-Ehle, P Belfrage
Jan 31, 1972·Biochemical and Biophysical Research Communications·W V Brown, M L Baginsky
Oct 1, 1970·Journal of Dairy Science·E W AskewJ W Thomas
May 7, 1971·Biochemical and Biophysical Research Communications·T OlivecronaU Lindahl
Jun 1, 1954·The Biochemical Journal·R K MORTON

Citations

Dec 1, 1985·Journal of Dairy Science·C D Azzara, P S Dimick
Mar 1, 1977·Journal of Dairy Science·J H NelsonR E Pitas
May 1, 1989·Journal of Dairy Science·C D Azzara, P S Dimick
Jan 18, 2014·The Journal of Dairy Research·Jing LuKasper Hettinga
Apr 1, 1978·Journal of the American Oil Chemists' Society·Robert G JensenK E McMahon
May 1, 1990·Indian Journal of Pediatrics·N R Mehta, K N Subramanian
Jul 1, 1977·Journal of Dairy Science·A Bexkorovainy

Related Concepts

Apoproteins
Bile Salts
Bos indicus
Enzyme Activation
Liquaemin
Hydrogen-Ion Concentration
Lipoprotein LIPASE
Milk, Human
Protamine Sulfate (USP)
Plasma Protein Binding Capacity

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