Milk oligosaccharides and metabolism in infants.

Advances in Nutrition
Silvia Rudloff, Clemens Kunz

Abstract

Since the discovery of human milk oligosaccharides (HMO) >60 y ago, research has faced major challenges including (i) the development of methods to identify and characterize these components, (ii) the need to use HMO fractions for functional studies because single HMO were not available, (iii) the uncertainty of the purity of HMO fractions that were often "contaminated" by remainders of lactose, proteins, or glycoproteins, and (iv) the low availability of large quantities of a single HMO for animal and human studies. In the past 10 years, there has been tremendous progress in all of these areas, particularly in the development of methods for detailed structural analysis in extremely low milk volumes. The greatest success, however, is that biotechnological means are available today to produce large amounts even of a single HMO in a purity that allows human studies to be performed in the future. In this review, we summarize the current knowledge about the metabolic aspects of HMO in infants starting with the first studies by Lundblad and co-workers in the early 1980s. After discussing newer observations in recent years, the review closes with a perspective on some important questions regarding metabolic and functional aspects of ...Continue Reading

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Citations

May 16, 2012·Advances in Nutrition·Clemens KunzSharon M Donovan
Nov 20, 2013·Nutrition Reviews·Esther Castanys-MuñozPedro Antonio Prieto
Nov 28, 2012·Pediatric Clinics of North America·Olivia Ballard, Ardythe L Morrow
Oct 21, 2014·Molecular Nutrition & Food Research·Viktoria DotzClemens Kunz
Nov 12, 2014·Annual Review of Animal Biosciences·Alline R PachecoDavid A Mills
Jul 17, 2013·Journal of Agricultural and Food Chemistry·Bernd O KellerSheila M Innis
Sep 22, 2016·Journal of Proteome Research·Flaminia Cesare MarincolaMauro Stronati
Feb 20, 2016·Food and Nutrition Bulletin·Benedikte GrenovKim F Michaelsen
Sep 8, 2016·Journal of Pediatric Gastroenterology and Nutrition·Clemens KunzSilvia Rudloff
Jul 23, 2014·Molecular & Cellular Proteomics : MCP·Ying YuDavid F Smith
Jan 18, 2018·Molecular Nutrition & Food Research·Vasily MorozovClemens Kunz
May 22, 2019·Nutrition Reviews·Alba Boix-AmorósDaniel Munblit
Aug 8, 2019·Journal of Applied Toxicology : JAT·Kirt R PhippsChristoph H Röhrig
Jul 18, 2018·Frontiers in Pediatrics·Vassilis TriantisR J Joost van Neerven
May 31, 2018·Advances in Nutrition·Daphna K Dror, Lindsay H Allen
Apr 4, 2013·The American Journal of Clinical Nutrition·Raul Cabrera-RubioM Carmen Collado
Mar 17, 2016·Advances in Nutrition·Esther Castanys-MuñozEnrique Vazquez
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Helle Katrine Knutsen
Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Helle Katrine Knutsen
Oct 19, 2017·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Wanli XuXiaomei Cong
Apr 4, 2021·Metabolic Engineering·Angela ZhangShota Atsumi
Apr 25, 2021·Pediatrics and Neonatology·Yu-Jyun Cheng, Chun-Yan Yeung
May 25, 2021·World Journal of Gastroenterology : WJG·Steve M D'SouzaDavid A Johnson
Jul 6, 2021·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Helle Katrine Knutsen
Jun 18, 2021·Molecular Nutrition & Food Research·Silvia RudloffClemens Kunz

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