Milk peptides and immune response in the neonate

Advances in Experimental Medicine and Biology
I Politis, R Chronopoulou

Abstract

Bioactive peptides encrypted within the native milk proteins can be released by enzymatic proteolysis, food processing, or gastrointestinal digestion. These peptides possess a wide range of properties, including immunomodulatory properties. The first months of life represent a critical period for the maturation of the immune system because a tolerance for nutrient molecules should be developed while that for pathogen-derived antigens is avoided. Evidence has accumulated to suggest that milk peptides may regulate gastrointestinal immunity, guiding the local immune system until it develops its full functionality. Our data using the weaning piglet as the model suggest that several milk peptides can downregulate various immune properties at a time (one to two weeks after weaning) that coincides with immaturity of the immune system. The protein kinase A system and/or the exchange protein directly activated by cyclic AMP (Epac-1) are implicated in the mechanism through which milk peptides can affect immune function in the early postweaning period. Despite the fact that the research in this field is in its infancy, the evidence available suggests that milk protein peptides may promote development of neonatal immune competence. Milk co...Continue Reading

Citations

Feb 6, 2010·European Journal of Pediatrics·C M Frank Kneepkens, Paul L P Brand
Jul 6, 2010·The Proceedings of the Nutrition Society·Fermín Sánchez de MedinaOlga Martínez-Augustin
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·T T WheelerK Stelwagen
Jun 10, 2015·Journal of Zhejiang University. Science. B·Tao-lin YuanJun-jun Wang
Sep 8, 2016·The Journal of Dairy Research·Georgios Theodorou, Ioannis Politis
Feb 6, 2017·Proteome Science·Lina ZhangKasper Hettinga
Aug 31, 2014·Molecular & Cellular Proteomics : MCP·Andres GuerreroCarlito B Lebrilla
Aug 8, 2014·Pediatric Pulmonology·Christian Rosas-SalazarJuan C Celedón
Dec 6, 2014·Proteomics·Sascha Sauer, Toni Luge
Apr 12, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Ralf G Heine, Mimi Lk Tang
Feb 22, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anna SandinLennart Bråbäck
Nov 15, 2008·Journal of Agricultural and Food Chemistry·Alberto FinamoreElena Mengheri
Aug 28, 2021·Biomedicines·Wararat ChiangjongSomchai Chutipongtanate

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.