PMID: 9003220Jan 1, 1997Paper

Milk-responsive atopic dermatitis is associated with a casein-specific lymphocyte response in adolescent and adult patients

The Journal of Allergy and Clinical Immunology
T WerfelC Neumann

Abstract

Specific T-cell responses to food antigens have been described in children with atopic dermatitis (AD). However, a subgroup of adolescent and adult patients still experiences food-responsive AD. This study was designed to evaluate lymphocyte responses to bovine casein in adult patients with AD. The stimulatory capacity of lipopolysaccharide-depleted bovine casein was tested in proliferation assays and in limiting dilution assays. Casein-specific T-cell clones (TCCs) were generated and characterized. Higher proliferative responses to casein and modulation of cytokine receptors were observed in patients with milk-responsive AD compared with individuals without clinical reactions on milk ingestion. The results did not correlate with the amount of casein-specific IgE in the serum. The frequencies of T cells that grew in the presence of casein or house dust mite antigens were similar. Only 27% of CD4+ casein-specific TCCs from these patients, but the majority of house dust mite-specific TCCs, produced IL-4 on mitogen stimulation. Interferon-gamma, on the other hand, was produced by the majority of TCCs with both specificities. A specific T-cell-mediated immune response to casein can be found in the blood of adolescent and adult pati...Continue Reading

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Citations

Jan 23, 1999·Current Opinion in Immunology·T T MacDonald
Sep 12, 1998·Lancet·D Rudikoff, M Lebwohl
Oct 27, 2010·The British Journal of Dermatology·A HeratizadehT Werfel
Jan 23, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W Peng, N Novak
Jun 29, 2010·Seminars in Cutaneous Medicine and Surgery·Ki-Young Suh
Apr 12, 2001·Allergy·T Werfel
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L PeltoS Salminen
May 18, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K BreuerT Werfel
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Wistokat-WülfingT Werfel
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P S Friedmann
Sep 3, 2002·American Journal of Respiratory and Critical Care Medicine·Alain MichilsPierre Rocmans
Oct 28, 2004·Molecular Nutrition & Food Research·Barbara Bohle
Sep 7, 2004·Current Opinion in Allergy and Clinical Immunology·Thomas Werfel, Kristine Breuer
Dec 2, 2004·Journal of Pediatric Gastroenterology and Nutrition·Samuli Rautava, Erika Isolauri
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K-M JärvinenH Suomalainen
Jan 22, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M LehtoH Alenius
Jun 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R P SchadeE van Hoffen
May 27, 2011·Current Allergy and Asthma Reports·Annice HeratizadehThomas Werfel
Nov 13, 2001·Allergy·K BreuerT Werfel
Aug 26, 2014·Current Opinion in Allergy and Clinical Immunology·Seshi ManamCarsten Flohr
Feb 11, 2019·International Archives of Allergy and Immunology·Dagmar SimonHans-Uwe Simon

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