Milky spots: omental functional units and hotbeds for peritoneal cancer metastasis

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Jiu-Yang LiuYan Li

Abstract

As the most common metastatic disease of abdomen pelvic cavity cancer, peritoneal carcinomatosis (PC) renders significant negative impact on patient survival and quality of life. Invasive peritoneal exfoliated cancer cells (PECCs) preferentially select the omentum as a predominant target site for cancer cell colonization and proliferation compared with other tissues in the abdominal cavity. The precise pathogenic mechanism remains to be determined. As omental milky spots (MSs) are the major implantation site for malignant cells in peritoneal dissemination, researches on mechanisms of PC have been mainly focused on MS, primitive lymphoid tissues with unique structural features, and functional characteristics. To date, extensive biophysical and biochemical methods have been manipulated to investigate the MS exact function in the peritoneal cavity. This review summarized MS as hotbeds for PECC. The anatomical distribution was briefly described first. Then, MS histology was systematically reviewed, including morphological features, cellular constituents, and histological staining methods. At last, the roles of MS in PC pathological process were summarized with special emphasis on the distinct roles of macrophages.

References

Nov 9, 1991·Lancet·J W Koten, W den Otter
Jun 1, 1991·Cell and Tissue Research·M ShimotsumaK Dux
Jan 1, 1988·Advances in Experimental Medicine and Biology·R H BeelenC D Dijkstra
Nov 1, 1986·Current Problems in Surgery·R Williams, H White
Jan 1, 1996·European Journal of Clinical Investigation·A LogmansH E van Ingen
Feb 1, 1996·The Anatomical Record·E Van VugtR H Beelen
Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·H TsujimotoT Takahashi
Feb 12, 1998·The Anatomical Record·L F KristR H Beelen
Oct 26, 2001·Journal of the Society for Gynecologic Investigation·C A WitzR S Schenken
Oct 31, 2002·Nature Immunology·Gavin P DunnRobert D Schreiber
Jul 30, 2003·Cancer Metastasis Reviews·C Pablo CarmignaniPaul H Sugarbaker
Aug 5, 2003·Virchows Archiv : an International Journal of Pathology·Sylvia StadlmannFelix Albert Offner
Nov 1, 2003·The International Journal of Biochemistry & Cell Biology·Steven E Mutsaers
Dec 29, 2004·Physiology & Behavior·Hans Hauner
Jan 12, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S J OosterlingJ R M van der Sijp
Jan 22, 2005·Anatomy and Embryology·Sylwia WilkoszSarah E Herrick
May 3, 2005·Nature Reviews. Cancer·Honami Naora, Denise J Montell
Jul 23, 2005·Clinical & Experimental Metastasis·Kathryn M BurlesonAmy P N Skubitz
Oct 22, 2005·Diagnostic Cytopathology·Jareer KassisElise C Kohn
Dec 2, 2005·Clinical & Experimental Metastasis·Nawar A AlkhamesiAra W Darzi
Dec 16, 2005·Neurological Research·I García-GómezP Cuevas
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Feb 15, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A A Ayantunde, S L Parsons
May 1, 2007·Cell and Tissue Research·Natalia O LitbargAshok K Singh
Jun 19, 2007·Cancer Research·Toni M Robinson-SmithAngela F Drew
Jul 14, 2007·The International Journal of Artificial Organs·G SacchiG Garosi
Feb 12, 2009·Cancer Research·Jill K Slack-DavisMark Conaway
Mar 3, 2009·Immunologic Research·Elizabeth W SorensenEdith M Lord

❮ Previous
Next ❯

Citations

Apr 15, 2016·Clinical & Experimental Metastasis·Nina SluiterElisabeth Atie Te Velde
Jul 25, 2019·Adipocyte·Yoon Jin Cha, Ja Seung Koo
Nov 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xinkai JiaPéter Balogh
Jul 4, 2020·Diseases of the Colon and Rectum·Isabelle BonnefoyGuillaume Passot
Sep 19, 2019·Toxicologic Pathology·Cynthia L Willard-MackCharlotte M Keenan
Jun 17, 2020·Frontiers in Immunology·Caleb N Muefong, Jayne S Sutherland
Jun 24, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K B MathieuR C Bast
Jan 21, 2021·International Journal of Molecular Sciences·Faye K TsogasPeter C Hart
Feb 20, 2021·Seminars in Cancer Biology·M CummingsN M Orsi
May 18, 2020·Cellular Oncology (Dordrecht)·Meysam YousefiAlireza Pasdar
Jul 23, 2021·Cancer Cell International·Jiuyang LiuGaosong Wu
Sep 27, 2018·Seminars in Cell & Developmental Biology·Arnoud W KasteleinChristianne A R Lok

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.