journal cover

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

Proceedings of the National Academy of Sciences of the United States of America

Nov 12, 2019

Michael A MetrickByron W Caughey

Get paper from

Abstract

Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that ...read more

Mentioned in this Paper

Alzheimer's Disease
Biological Markers
Chronic Disease
Deer (mammal)
Environment
Ions
Creutzfeldt-Jakob Disease
Tau Proteins
Prion Diseases
Alpha-Synuclein
16
1
12
Paper Details
References
  • References
  • Citations1
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.

Similar Papers Found In These Feeds

Molecular diagnostic strategies in prion disease

Prion diseases are fatal neurodegenerative and infectious disorders characterized by structural transition of the host-encoded cellular prion protein into the aberrantly folded pathologic isoform of the protein. Here is the latest research on molecular diagnostic strategies for prion diseases.

Creutzfeldt-Jakob Disease

Creutzfeldt-Jakob Disease is a fatal neurodegenerative disease caused due to aggregation and accumulation of misfolded prion proteins. Here are the latest discoveries pertaining to this disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a chronic neurodegenerative disease. This feed focuses on the underlying role of Tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's.

Prion Disease: Cholesterol

The Prion Disease: Cholesterol feed describes the role cholesterol plays in the conversion and transmission of prion. Discover the latest research on the role of cholesterol in prion disease here.

Tauopathies

Tauopathies are neurodegenerative disorders caused due to misfolding and aggregation of the tau protein in neurofibrillary tangles in the brain. Discover the latest research on tauopathies here.

Gerstmann-Straussler-Scheinker Disease

Gerstmann-Straussler-Scheinker disease is a rare neurodegenerative disorder caused by prions and characterized by symptoms associated with prion-associated diseases. Here is the latest research.

Prion Disease

Prion diseases or transmissible spongiform encephalopathies are rare progressive neurogenerative diseases caused by misfolded prion proteins. Here is the latest research in this domain.

Prion Diseases: Biomarkers

Prions are misfolded proteins which characterize several fatal neurodegenerative diseases. Prion proteins, as an important biomarker of prion disease, are responsible for the transmissible spongiform encephalopathies. Here is the latest research investigating biomarkers in prion diseases.

Frontotemporal Lobar Degeneration

Frontotemporal lobar degeneration or frontotemporal dementia refers to a group of uncommon disorders that occur as a result of progressive nerve cell loss in the frontal and temporal lobes of the brain. Here is the latest research.

Proteostasis

Proteostasis enables the maintenance of protein homeostasis via modulation of protein translation, enhancement of chaperone capacity and the prompt clearance of misfolded proteins. It is affected in several neurodegenerative diseases. Here is the latest research.

α-Synuclein Structure and Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Alpha-Synuclein Aggregation

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Tau Aggregation: Genomics

Tau Aggregation is an important characteristic in some neurodegenerative disorders, including Alzheimer’s Disease. Discover the latest research using genomics to understand Tau Aggregation.

Misfolding & Aggregation Diseases

Misfolding and aggregation of proteins can lead to several diseases. For instance, misfolding of prion or tau proteins are associated with several neurodegenerative diseases. Here is the latest research on diseases caused by protein misfolding and aggregation.

Prion Neurodegeneration

Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (prp). Here is the latest research on prion diseases.

Misfolded Proteins: ND

Protein misfolding is the primary cause of several neurodegenerative disease, including Alzheimer’s and Parkinson’s disease. Here is the latest research.

Alpha-Synuclein Structure and Function

α-Synuclein is an integral component of Lewy bodies which are comprised of protein clumps and are a pathological hallmark of Parkinson’s disease. Here is the latest research on α-Synuclein structure and function.

Synucleinopathies

Synucleinopathies are neurodegenerative diseases characterized by accumulation of alpha-synuclein protein aggregates in neurons and glial cells. Discover the latest research on synucleinopathies here.

© 2019 Meta ULC. All rights reserved

Million-fold sensitivity enhancement in proteopathic seed amplification assays for biospecimens by Hofmeister ion comparisons

Proceedings of the National Academy of Sciences of the United States of America

Nov 12, 2019

Michael A MetrickByron W Caughey

PMID: 31641070

DOI: 10.1073/pnas.1909322116

Abstract

Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that ...read more

Mentioned in this Paper

Alzheimer's Disease
Biological Markers
Chronic Disease
Deer (mammal)
Environment
16
1
12

Similar Papers Found In These Feeds

Related Papers

Paper Details
References
  • References
  • Citations1
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.

Get paper from

/papers/million-fold-sensitivity-enhancement-in/31641070