Millisecond light pulses make mice stop running, then display prolonged sleep-like behavior in the absence of light.

Journal of Biological Rhythms
Lawrence P Morin, Keith M Studholme

Abstract

Masking, measured as a decrease in nocturnal rodent wheel running, is a visual system response to rod/cone and retinal ganglion cell photoreception. Here, the authors show that a few milliseconds of light are sufficient to initiate masking, which continues for many minutes without additional photic stimulation. C57J/B6 mice were tested using flash stimuli previously shown to elicit large circadian rhythm phase shifts. Ten flashes, 2 msec each and equally distributed over 5 min, activate locomotor suppression that endures for an additional 25 to 35 min in the dark and does not differ in magnitude or duration from that elicited by 5-min saturating light pulse. Locomotor activity by mice without access to running wheels is also suppressed by light flashes. The effects of various light flash patterns on mouse locomotor suppression are similar to those previously described for hamster phase shifts. Video analysis of active mice indicates that light flashes initiated at ZT13 rapidly induce an interval of behavioral quiescence that lasts about 10 min at which time the animals assume a typical sleep posture that is maintained for an additional 25 min. Thus, the period coincident with light-induced wheel running suppression appears to c...Continue Reading

References

Jan 1, 1989·Chronobiology International·L Rensing
Jan 1, 1989·Chronobiology International·D S Minors, J M Waterhouse
Feb 1, 1987·Sleep·B M BergmannA Rechtschaffen
Aug 1, 1994·Chronobiology International·P RedfernJ Waterhouse
Aug 4, 1998·The American Journal of Physiology·A N Van Den PolH C Heller
Jun 23, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·N MrosovskyP A Salmon
Jun 23, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·U Redlin, N Mrosovsky
Jun 23, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·U Redlin, N Mrosovsky
Jun 23, 1999·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·U RedlinN Mrosovsky
Aug 12, 1999·Chronobiology International·N Mrosovsky
Oct 13, 2000·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·E B Ottoni
Oct 31, 2001·Brain Research·K Edelstein, N Mrosovsky
Jan 5, 2002·Journal of Biological Rhythms·N MrosovskyR G Foster
Jun 28, 2003·Science·Satchidananda PandaJohn B Hogenesch
Jan 1, 1960·Cold Spring Harbor Symposia on Quantitative Biology·J ASCHOFF
Dec 19, 2003·Chronobiology International·N Mrosovsky, S Hattar
Sep 28, 2004·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Xiaodong LiFred C Davis
Nov 9, 2005·Journal of Biological Rhythms·Louise Muscat, Lawrence P Morin
Jun 1, 2006·The Journal of Comparative Neurology·Samer HattarDavid M Berson
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luis Vidal, Lawrence P Morin
Apr 17, 2008·The European Journal of Neuroscience·Stewart ThompsonN Mrosovsky
Dec 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·C M AltimusS Hattar
Jan 23, 2009·Nature Neuroscience·Daniela LupiRussell G Foster

❮ Previous
Next ❯

Citations

May 21, 2010·Journal of Biological Rhythms·Lawrence P MorinKeith M Studholme
Jul 16, 2011·PloS One·Jamie M ZeitzerH Craig Heller
Feb 1, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keith M StudholmeLawrence P Morin
Sep 22, 2010·Chronobiology International·Pablo VivancoJuan Antonio Madrid
Aug 21, 2014·Frontiers in Systems Neuroscience·Fanuel MuindiHorace Craig Heller
Sep 7, 2016·Neuroscience·Ramalingam VetrivelanClifford B Saper
Sep 19, 2014·Journal of Biological Rhythms·Lawrence P Morin, Keith M Studholme
Aug 4, 2010·Journal of Biological Rhythms·A PowerH D Piggins
Mar 5, 2020·Journal of Neuroscience Research·Alexandra M YawHanne M Hoffmann
Apr 23, 2013·Journal of Biological Rhythms·Lawrence P Morin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.