Mimicking stem cell niches to increase stem cell expansion.

Current Opinion in Biotechnology
Shara M DellatoreWilliam M Miller

Abstract

Niches regulate lineage-specific stem cell self-renewal versus differentiation in vivo and are composed of supportive cells and extracellular matrix components arranged in a three-dimensional topography of controlled stiffness in the presence of oxygen and growth factor gradients. Mimicking stem cell niches in a defined manner will facilitate production of the large numbers of stem cells needed to realize the promise of regenerative medicine and gene therapy. Progress has been made in mimicking components of the niche. Immobilizing cell-associated Notch ligands increased the self-renewal of hematopoietic (blood) stem cells. Culture on a fibrous scaffold that mimics basement membrane texture increased the expansion of hematopoietic and embryonic stem cells. Finally, researchers have created intricate patterns of cell-binding domains and complex oxygen gradients.

References

Feb 4, 2006·Chembiochem : a European Journal of Chemical Biology·Jwa-Min NamJay T Groves
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ali KhademhosseiniJoseph P Vacanti
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Junsang Doh, Darrell J Irvine
May 3, 2006·Lab on a Chip·Jaehyun ParkMichel M Maharbiz
Jun 8, 2006·Journal of Biomedical Materials Research. Part a·Benjamin L BecksteadCecilia M Giachelli
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Jan 24, 2007·Journal of Biomedical Materials Research. Part a·Gaye CetinkayaAşkin Tümer
Feb 1, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Chou Chai, Kam W Leong
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Bryan L Jackson, Jay T Groves
Mar 21, 2007·Blood·Mo A DaoCatherine M Verfaillie
Mar 29, 2007·Biomacromolecules·Hwei Ling KhorDietmar W Hutmacher
May 8, 2007·ACS Chemical Biology·Ratmir DerdaLaura L Kiessling
Jun 15, 2007·Journal of Cellular Biochemistry·Masato NagaokaToshihiro Akaike
Jul 25, 2007·Journal of Biomedical Materials Research. Part a·D ThidJ Gold
Jul 28, 2007·Current Opinion in Chemical Biology·James A King, William M Miller
Sep 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Rico C GunawanWilliam M Miller
Sep 28, 2007·Biochemical and Biophysical Research Communications·Kentaro HosokawaToshio Suda
Oct 9, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Dorota ThidJulie Gold
Oct 20, 2007·Science·Haeshin LeePhillip B Messersmith
Nov 13, 2007·Advanced Drug Delivery Reviews·Eileen DawsonKrishnendu Roy
Nov 30, 2007·Developmental Neurobiology·Takuro MaruyamaNobuhiko Yamamoto
Jan 12, 2008·Bioconjugate Chemistry·Tadashi Nakaji-HirabayashiHiroo Iwata
Jan 18, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Ji Youn LeeAlexander Revzin
Jun 17, 2008·Nature Methods·Kristin AlbertiPeter W Zandstra

❮ Previous
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Citations

Apr 30, 2010·Cellular and Molecular Life Sciences : CMLS·Jenny Kruegel, Nicolai Miosge
Jan 19, 2013·ACS Applied Materials & Interfaces·Sabrina Schlie-WolterBoris N Chichkov
Feb 9, 2013·Chemical Reviews·Akon HiguchiAkihiro Umezawa
Nov 27, 2009·Nature·Matthias P LutolfHelen M Blau
Feb 20, 2010·Nature Reviews. Cancer·Robert R Jenq, Marcel R M van den Brink
Feb 24, 2011·Seminars in Liver Disease·Luca Fabris, Mario Strazzabosco
Nov 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sidi A BencherifDavid J Mooney
May 8, 2013·Journal of Biomaterials Science. Polymer Edition·Shui GuanZhan-Feng Cui
Apr 22, 2010·Journal of Medicinal Food·István KissIstván Ember
Jun 26, 2009·Tissue Engineering. Part B, Reviews·Bari MurtuzaAli Khademhosseini
Aug 3, 2010·Tissue Engineering. Part C, Methods·Martin GrueneBoris Chichkov
Apr 5, 2013·Journal of the Royal Society, Interface·Deepak M KalaskarRachel L Williams
Apr 17, 2010·Nanomedicine·Hikmet GeckilUtkan Demirci
Sep 28, 2013·Biochemistry Research International·Nanako KawaguchiYohtaroh Takagaki
Aug 24, 2013·International Journal of Pharmaceutics·Yen-Pei LuKeng-Shiang Huang
May 14, 2014·Journal of Biomechanics·Farshid GuilakFrank P T Baaijens
Mar 29, 2014·Experimental Hematology·Eun-ju LeeDavid Haylock
Dec 11, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Guorui Jin, Kai Li
Feb 20, 2013·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Johannes Menzel-SeveringUrsula Schlötzer-Schrehardt
Nov 6, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Aleksander SkardalShay Soker
Dec 21, 2010·Biomaterials·Nurazhani Abdul RaofDavid T Corr
Sep 25, 2010·International Journal of Cardiology·Mitsuyo MachidaNanako Kawaguchi
Aug 4, 2009·Advanced Drug Delivery Reviews·Shawn H Lim, Hai-Quan Mao
Apr 23, 2009·Journal of Cellular and Molecular Medicine·L M PopescuMaria Simonetta Faussone-Pellegrini
Sep 20, 2011·Journal of Cellular Physiology·Yonghua ZhengXiangdong Wang
Mar 31, 2011·Journal of Biomedical Materials Research. Part a·Sing Yian Chew, Wei Ching Low
Dec 21, 2010·Journal of Biomedical Materials Research. Part a·Morten HansenNiels B Larsen
Aug 31, 2010·Journal of Cellular Biochemistry·Boudewijn van der SandenDidier Wion
Jul 28, 2011·International Journal of Cancer. Journal International Du Cancer·Stephanie M CabarcasWilliam L Farrar
Oct 13, 2016·Journal of Tissue Engineering and Regenerative Medicine·Nolan B SkopSteven W Levison
Mar 13, 2010·Biotechnology and Applied Biochemistry·Aldo Leal-Egaña, Thomas Scheibel
Jan 11, 2014·Biotechnology Journal·Guillaume F RousseauLuc Douay
Jan 14, 2010·Biotechnology and Bioengineering·Tiago G FernandesJonathan S Dordick
Apr 24, 2012·Biomaterials·Mehdi NikkhahAli Khademhosseini

❮ Previous
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