Mimicry between neurokinin-1 and fibronectin may explain the transport and stability of increased substance P immunoreactivity in patients with bone marrow fibrosis.

Blood
P RameshwarX Song

Abstract

Bone marrow (BM) fibrosis may occur in myeloproliferative diseases, lymphoma, myelodysplastic syndrome, myeloma, and infectious diseases. In this study, the role of substance P (SP), a peptide with pleiotropic functions, was examined. Some of its functions-angiogenesis, fibroblast proliferation, and stimulation of BM progenitors-are amenable to inducing BM fibrosis. Indeed, a significant increase was found in SP-immunoreactivity (SP-IR) in the sera of patients with BM fibrosis (n = 44) compared with the sera of patients with hematologic disorders and no histologic evidence of fibrosis (n = 46) (140 +/-12 vs 18 +/-3; P <.01). Immunoprecipitation of sera SP indicated that this peptide exists in the form of a complex with other molecule(s). It was, therefore, hypothesized that SP might be complexed with NK-1, its natural receptor, or with a molecule homologous to NK-1. To address this, 3 cDNA libraries were screened that were constructed from pooled BM stroma or mononuclear cells with an NK-1 cDNA probe. A partial clone (clone 1) was retrieved that was 97% homologous to the ED-A region of fibronectin (FN). Furthermore, sequence analyses indicated that clone 1 shared significant homology with exon 5 of NK-1. Immunoprecipitation and...Continue Reading

References

Jun 1, 1992·The Journal of Investigative Dermatology·J E KrauseA D Hershey
Jul 1, 1991·The International Journal of Neuroscience·E WeiheJ Krekel
Aug 1, 1987·British Journal of Haematology·B R GreenbergF R Ahmann
Jan 1, 1985·British Journal of Haematology·D M McCarthy
Mar 1, 1985·British Journal of Haematology·J T ReillyB A McVerry
Sep 1, 1985·The American Journal of Medicine·L VandermolenE C Lynch
Aug 1, 1984·The American Journal of Medicine·J L SpivakT C Quinn
Jun 9, 1995·International Journal of Cancer. Journal International Du Cancer·I M HennigJ C Reubi
Sep 1, 1994·British Journal of Haematology·J T Reilly
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·N D BoydS E Leeman
Jan 1, 1996·Nephron·S NomuraH Nagahana
Mar 1, 1996·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·C A Maggi
Nov 1, 1996·Acta histochemica·Z TabarowskiS Y Felten
Nov 5, 1997·Clinical Immunology and Immunopathology·P Rameshwar
Apr 15, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V H van der Velden, A R Hulsmann
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G Barosi
Nov 30, 1999·Trends in Pharmacological Sciences·M Malcangio, N G Bowery
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·D SinghP Rameshwar
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·N KaminskiR A Heller
Apr 27, 2000·The New England Journal of Medicine·A Tefferi
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I Marriott, K L Bost
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P RameshwarP Gascon
Aug 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S FranitzaO Lider
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J QianP Rameshwar

❮ Previous
Next ❯

Citations

Jun 16, 2012·Expert Opinion on Therapeutic Patents·Miguel MuñozRafael Coveñas
Feb 22, 2011·Peptides·Stanislas Grassin-DelyleHélène Merle-Béral
Jun 18, 2016·Cellular and Molecular Life Sciences : CMLS·Alireza MashaghiReza Dana
Sep 29, 2020·Journal of Cellular and Molecular Medicine·Hyun Sook HongYoungsook Son
Nov 20, 2017·Tissue Engineering and Regenerative Medicine·Ji Eun Lim, Youngsook Son
May 13, 2015·Journal of Biosciences·Miguel MunozMaximino Redondo
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J QianP Rameshwar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.