Mind the gap: Multiple events and lengthy delays before presentation with a "first seizure"

Epilepsia
Anna L FirkinAnne M McIntosh

Abstract

Up to half of patients assessed for suspected new-onset epileptic seizures report previous undiagnosed events. This suggests that delay to timely and expert assessment is a major issue. Very little is known about the degree of delay or nature of the undiagnosed events, impacting on our understanding of new-onset epilepsy. In this study we aimed to examine events that occur before presentation, as well as the extent and risk factors for delay to assessment. Included in this retrospective study were 220 patients diagnosed at the First Seizure Clinic (Austin Health, Australia) between 2003 and 2006 with an epileptic index seizure. Patients with a prior diagnosis of epileptic seizures were excluded. Chart review was undertaken, including detailed interviews conducted by an epileptologist at first assessment. Logistic regression assessed risk factors for delay from first event to presentation, including event characteristics, socioeconomic disadvantage, employment, and distance to medical facility. Forty-one percent (n = 90) of patients had one or more event before their index seizure. Of these, 50% had multiple or more than five prior events and 28% experienced one or more convulsive event before the index seizure. Of the total 220...Continue Reading

References

Jan 1, 1995·International Journal of Technology Assessment in Health Care
Sep 16, 1999·Epilepsia·M A KingS F Berkovic
Feb 5, 2000·The New England Journal of Medicine·P Kwan, M J Brodie
May 23, 2001·International Journal of Epidemiology·G Turrell, C Mathers
Feb 1, 2003·Epilepsia·Suthida YenjunSamuel F Berkovic
Mar 25, 2005·Emergency Medicine Journal : EMJ·M J G DunnA J Gray
Feb 1, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J J N van LaarK Stronks
Feb 13, 2007·Epilepsy & Behavior : E&B·Sarah L VelissarisSamuel F Berkovic
Feb 22, 2008·Epilepsia·Anne T Berg
Feb 22, 2008·Epilepsia·Samuel WiebeMichelle Shapiro
Feb 25, 2009·Australian and New Zealand Journal of Public Health·Peter FeldmanMargaret Kelaher
Apr 27, 2010·Australian Dental Journal·UNKNOWN Australian Research Centre for Population Oral Health, The University of Adelaide, South Australia
Apr 13, 2011·Social Science & Medicine·Thomas Astell-BurtJohn F Dillon
Sep 1, 2012·Epilepsy Currents·Lisa M BatemanWilliam H Theodore
Oct 9, 2012·Epilepsy & Behavior : E&B·Mary Jane EnglandLarisa M Strawbridge

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Citations

Jan 23, 2016·Nature Reviews. Neurology·Christian E Elger
Feb 26, 2016·CNS Drugs·David S Gloss, Allan Krumholz
Apr 3, 2016·Clinical Neurology and Neurosurgery·Igor KuzmanovskiRozalinda Isjanovska
Oct 25, 2016·The American Journal of Cardiology·Chien-Yi HsuShing-Jong Lin
Nov 12, 2016·Biochemical and Biophysical Research Communications·Rainer SurgesAlexander Pfeifer
May 4, 2018·Nature Reviews. Disease Primers·Orrin DevinskyPiero Perucca
Jan 31, 2018·Orphanet Journal of Rare Diseases·Monika SłowińskaKatarzyna Kotulska-Jóźwiak
Dec 20, 2017·Current Opinion in Neurology·Albrecht Kunze, Markus Reuber
Apr 6, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Emma FosterPatrick Kwan
Dec 15, 2019·Emergency Medicine Australasia : EMA·Sarah HolperPatrick Kwan
Aug 19, 2020·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jacob PellinenUNKNOWN Human Epilepsy Project Investigators
Oct 11, 2020·BMJ : British Medical Journal·Zhibin ChenPatrick Kwan
Oct 21, 2020·Epilepsia·Jacob PellinenUNKNOWN Human Epilepsy Project Co-Investigators
Jan 14, 2021·Brain : a Journal of Neurology·Kasper LolkJakob Christensen
Dec 19, 2020·Epilepsia Open·Laura ParviainenLeena Jutila
Sep 5, 2020·Acta Neurologica Scandinavica·Eileen Mc ManusFredrik Asztely
May 18, 2021·Clinical Neurophysiology Practice·Naim HaddadZiyad Mahfoud
Jun 22, 2021·Epilepsia·Marie-Coralie CornetMaria Roberta Cilio
Nov 25, 2021·Current Neurology and Neuroscience Reports·Jacob PellinenKelly G Knupp

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