Mind the Gap: Sex Bias in Basic Skin Research

The Journal of Investigative Dermatology
Betty Y KongAmy S Paller

Abstract

Given the recent National Institutes of Health proposal for balanced use of male and female cells and animals in preclinical studies, we explored whether sex bias exists in skin research. We surveyed 802 dermatological research articles from 2012 through 2013. No information about the sex of studied cells or animals was provided in 60% of papers. Among keratinocytes of known sex, 70% were male. Few studies compared male versus female cells or animals. Disclosure of sex and comparative studies contribute to our understanding of the biologic basis of sex differences. Addressing sex-specific differences in preclinical research informs subsequent clinical trial design and promotes individualized therapy.

Citations

Jun 10, 2020·ELife·Nicole C WoitowichTeresa Woodruff
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Dec 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Moriah J CastlemanPamela R Hall
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Oct 26, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Susanne KimeswengerChristian Jantschitsch
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Feb 25, 2019·The Journal of Investigative Dermatology·Megan H Orzalli

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