Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides

Molecular Cell
David G Maranon, Jeffrey Wilusz

Abstract

While gapmers efficiently knock down as well as terminate transcription of nascent lncRNAs and mRNAs, Lee and Mendell (2020) and Lai et al. (2020) also demonstrate that Pol II termination is not observed with gapmers targeting the 3' terminal portions of the transcript.

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M L Stephenson, P C Zamecnik
Dec 26, 2002·The Journal of Biological Chemistry·Timothy A VickersBrenda F Baker
Feb 21, 2009·The FEBS Journal·Susana M Cerritelli, Robert J Crouch
Mar 5, 2014·Nucleic Acids Research·Amanda J WardFrank Rigo
Jul 1, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xue-Hai LiangStanley T Crooke
Jan 12, 2020·Molecular Cell·Jong-Sun Lee, Joshua T Mendell

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Citations

Nov 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haoyang ZhouMark W Feinberg

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