Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond

Journal of Cell Science
Bethany Lucas, Jeff Hardin

Abstract

The Slit-Robo GTPase-activating proteins (srGAPs) were first identified as potential Slit-Robo effectors that influence growth cone guidance. Given their N-terminal F-BAR, central GAP and C-terminal SH3 domains, srGAPs have the potential to affect membrane dynamics, Rho family GTPase activity and other binding partners. Recent research has clarified how srGAP family members act in distinct ways at the cell membrane, and has expanded our understanding of the roles of srGAPs in neuronal and non-neuronal cells. Gene duplication of the human-specific paralog of srGAP2 has resulted in srGAP2 family proteins that may have increased the density of dendritic spines and promoted neoteny of the human brain during crucial periods of human evolution, underscoring the importance of srGAPs in the unique sculpting of the human brain. Importantly, srGAPs also play roles outside of the nervous system, including during contact inhibition of cell movement and in establishing and maintaining cell adhesions in epithelia. Changes in srGAP expression may contribute to neurodevelopmental disorders, cancer metastasis and inflammation. As discussed in this Review, much remains to be discovered about how this interesting family of proteins functions in a...Continue Reading

References

Jan 1, 1978·American Journal of Diseases of Children·M Verjaal, M B De Nef
Nov 16, 1995·Nature·W HuangW Rink
May 10, 2002·Trends in Neurosciences·Ger J A Ramakers
Jul 13, 2002·Journal of Cellular Physiology·Lori B ChristersonMelanie H Cobb
Aug 27, 2002·Proceedings of the National Academy of Sciences of the United States of America·Volker EndrisGudrun A Rappold
Nov 26, 2002·Nature Cell Biology·Scott H SoderlingJohn D Scott
Feb 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Scott H SoderlingJohn D Scott
May 1, 1954·Experimental Cell Research·M ABERCROMBIE, J E HEAYSMAN
Aug 26, 2004·Developmental Biology·Pierre MattarCarol Schuurmans
Oct 8, 2004·Developmental Cell·Matthias KrauseFrank B Gertler
Feb 14, 2006·American Journal of Medical Genetics. Part a·Douglas C BittelMerlin G Butler
Jan 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Scott H SoderlingJohn D Scott
Jul 25, 2007·The Journal of Cell Biology·Soichiro Yamada, W James Nelson
Sep 7, 2007·Molecular and Cellular Neurosciences·D L VogtA T Malouf
Mar 11, 2008·Cell·Adam FrostVinzenz M Unger
Mar 18, 2008·Gene Expression Patterns : GEP·Robert WaltereitDusan Bartsch
May 24, 2008·Current Biology : CB·Christopher C QuinnWilliam G Wadsworth
Nov 14, 2008·Molecular Biology of the Cell·Maria Cristina StellaPaolo M Comoglio
Jan 13, 2009·The Journal of Comparative Neurology·Claire BaconGudrun Rappold
Jan 28, 2009·Biochimica Et Biophysica Acta·Harry Mellor
Sep 18, 2009·American Journal of Medical Genetics. Part a·Salwati ShuibEamonn R Maher
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yijian RaoVolker Haucke
May 27, 2010·Development·Athena R YpsilantiAlain Chédotal
Sep 3, 2010·The Journal of Biological Chemistry·Shaoshi Guo, Shilai Bao
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bu-Qing YeJian-Guo Geng
Nov 10, 2010·The Journal of Cell Biology·Ronen Zaidel-BarJeff Hardin
Nov 18, 2010·American Journal of Medical Genetics. Part a·Cecilia Gunnarsson, Cathrine Foyn Bruun
Nov 26, 2010·Nature Reviews. Molecular Cell Biology·Livio TrusolinoPaolo M Comoglio
Dec 15, 2010·The Journal of Biological Chemistry·Frank M MasonScott H Soderling
Dec 21, 2010·Nature Cell Biology·Lukas J NeukommMichael O Hengartner
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin R CarlsonScott H Soderling
Nov 23, 2011·American Journal of Medical Genetics. Part a·Hirotomo SaitsuNaomichi Matsumoto
Jan 25, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Zhi-Bing ChenXi-Nan Yi
Apr 3, 2012·Journal of Cell Science·Jaeda Coutinho-BuddFranck Polleux

❮ Previous
Next ❯

Citations

Dec 28, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bongjin ShinSun-Kyeong Lee
Jun 22, 2018·International Journal of Molecular Sciences·Valentina ZamboniGiorgio R Merlo
Oct 31, 2018·Human Genomics·Masoud ArabfardMina Ohadi
Aug 19, 2020·Nature Communications·Vikrant K BhosleLisa A Robinson
Jan 23, 2021·Cell Communication and Signaling : CCS·Emmanuelle Martinot, Derek Boerboom

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.