'Mind your Moles' study: protocol of a prospective cohort study of melanocytic naevi

BMJ Open
Uyen KohAdele C Green

Abstract

Having many melanocytic naevi or 'moles' on the skin is the strongest predictor of melanoma; thus, much can be learnt from investigating naevi in the general population. We aim to improve the understanding of the epidemiology and biology of naevi by conducting a 3-year prospective study of melanocytic naevi in adults. This is a population-based cohort study of melanocytic naevi in 200 adults aged 20-69 years recruited via the Australian electoral roll. At baseline, participants will complete a questionnaire on their sun behaviour and health and undergo a clinical examination. Three-dimensional (3D) total-body photography will be used to record the images of skin lesions. Pigmented naevi will be analysed in terms of number, diameter, colour and border irregularity using automated analysis software (excluding scalp, beneath underwear and soles of feet). All naevi ≥5 mm will be recorded using the integrated dermoscopy photographic system. A saliva sample will be obtained at baseline for genomic DNA analysis of pigmentation, naevus and melanoma-associated genes using the Illumina HumanCoreExome platform. The sun behaviour and health follow-up questionnaire, clinical examination and 3D total-body photography will be repeated every 6...Continue Reading

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Citations

Dec 14, 2019·The British Journal of Dermatology·B Betz-StableinA C Green
Mar 20, 2020·Australian and New Zealand Journal of Public Health·Monika JandaDavid C Whiteman
May 16, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·B Betz-StableinA C Green

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Methods Mentioned

BETA
Assay
Chip
genotyping
exome sequencing

Software Mentioned

Research Electronic Data Capture ( REDCap )
VECTRA

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