"Mindful" development of rapid, safe and effective COVID-19 vaccines

Expert Review of Vaccines
Leonard MoiseAnne S De Groot

Abstract

The world needs a vaccine urgently to recover from the COVID-19 pandemic. In the race to a vaccine, several companies and funders are pursuing the most obvious approach, which is to develop antibody-focused vaccines based on the SARS-CoV-2 spike glycoprotein antigen. Emphasis on one approach, while setting aside others, is no small gamble. We believe the urgency of the situation calls for pursuit of multiple paths to a safe and effective vaccine. T cell immunity is essential to resolve SARS-CoV-2 infection and is a critical component of immunity against related coronaviruses. A T cell-directed vaccine may stimulate viral clearance mechanisms that reduce morbidity and obviate the risk of antibody-dependent enhanced disease. Moreover, T cell-directed vaccines can be designed to recall memory against similar viruses and/or to stimulate immunity against SARS-CoV-2 and other highly pathogenic coronaviruses. Mindful development of T cell-epitope driven vaccines may help to protect against the current coronavirus outbreak and pathogenic coronaviruses that are likely to emerge and threaten humanity again.

References

Jan 6, 2006·The New England Journal of Medicine·Timo VesikariUNKNOWN Rotavirus Efficacy and Safety Trial (REST) Study Team
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Jul 22, 2014·Trends in Immunology·Nicole L La Gruta, Stephen J Turner
Aug 3, 2019·Science·Michelle C CrankUNKNOWN VRC 317 Study Team
Mar 17, 2020·The Journal of Infection·Jun ChenHongzhou Lu
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Jun 9, 2020·BioRxiv : the Preprint Server for Biology·Neeltje van DoremalenVincent J Munster
Jul 31, 2020·Nature·Neeltje van DoremalenVincent J Munster

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