Mindfulness-based stress reduction for people with multiple sclerosis - a feasibility randomised controlled trial

BMC Neurology
Robert SimpsonStewart W Mercer

Abstract

Multiple sclerosis (MS) is a stressful condition. Mental health comorbidity is common. Stress can increase the risk of depression, reduce quality of life (QOL), and possibly exacerbate disease activity in MS. Mindfulness-Based Stress Reduction (MBSR) may help, but has been little studied in MS, particularly among more disabled individuals. The objective of this study was to test the feasibility and likely effectiveness of a standard MBSR course for people with MS. Participant eligibility included: age > 18, any type of MS, an Expanded Disability Status Scale (EDSS) </= 7.0. Participants received either MBSR or wait-list control. Outcome measures were collected at baseline, post-intervention, and three-months later. Primary outcomes were perceived stress and QOL. Secondary outcomes were common MS symptoms, mindfulness, and self-compassion. Fifty participants were recruited and randomised (25 per group). Trial retention and outcome measure completion rates were 90% at post-intervention, and 88% at 3 months. Sixty percent of participants completed the course. Immediately post-MBSR, perceived stress improved with a large effect size (ES 0.93; p < 0.01), compared to very small beneficial effects on QOL (ES 0.17; p = 0.48). Depressio...Continue Reading

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Citations

Jun 26, 2018·The Clinical Neuropsychologist·Siew-Tim LaiVenus Tang
Jul 10, 2018·Multiple Sclerosis : Clinical and Laboratory Research·Angela SendersLynne Shinto
Jun 7, 2018·Frontiers in Behavioral Neuroscience·Barbara WillekensNathalie Cools
Jul 3, 2020·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Jennifer R MillerFrederick W Foley
Dec 2, 2020·BMJ Open·Irene Gil-GonzálezMaría Ángeles Pérez-San-Gregorio
Jan 22, 2021·Multiple Sclerosis and Related Disorders·Jennifer DunneLucinda J Black
Apr 21, 2021·Multiple Sclerosis : Clinical and Laboratory Research·Anthony M HarrisonSam Norton

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Methods Mentioned

BETA
cognitive behavioural therapy

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