Mindfulness-based stress reduction versus pharmacotherapy for chronic primary insomnia: a randomized controlled clinical trial

Explore : the Journal of Science and Healing
Cynthia R GrossMichel Cramer-Bornemann


The aim of this study was to investigate the potential of mindfulness-based stress reduction (MBSR) as a treatment for chronic primary insomnia. A randomized controlled trial was conducted. The study was conducted at a university health center. Thirty adults with primary chronic insomnia based on criteria of the Diagnostic and Statistical Manual of Mental Disorders, Text Revision, 4th Edition were randomized 2:1 to MBSR or pharmacotherapy (PCT). Mindfulness-based stress reduction, a program of mindfulness meditation training consisting of eight weekly 2.5 hour classes and a daylong retreat, was provided, with ongoing home meditation practice expectations during three-month follow-up; PCT, consisting of three milligrams of eszopiclone (LUNESTA) nightly for eight weeks, followed by three months of use as needed. A 10-minute sleep hygiene presentation was included in both interventions. The Insomnia Severity Index (ISI), Pittsburgh Sleep Quality Index (PSQI), sleep diaries, and wrist actigraphy were collected pretreatment, posttreatment (eight weeks), and at five months (self-reports only). Between baseline and eight weeks, sleep onset latency (SOL) measured by actigraphy decreased 8.9 minutes in the MBSR arm (P < .05). Large, sig...Continue Reading


Sep 15, 1989·JAMA : the Journal of the American Medical Association·D E Ford, D B Kamerow
Aug 28, 1998·Journal of Psychosomatic Research·J S Carpenter, M A Andrykowski
Jun 16, 1999·Journal of Consulting and Clinical Psychology·N S JacobsonJ B McGlinchey
Dec 22, 2000·Spine·J E Ware
Apr 20, 2001·JAMA : the Journal of the American Medical Association·J D EdingerR E Quillian
Jan 18, 2003·Sleep Medicine Reviews·Maurice M Ohayon
Aug 21, 2003·Sleep Medicine Reviews·Charles M Morin
Dec 17, 2003·Journal of Occupational Health·Machi SukaHiroki Sugimori
Jul 17, 2004·Journal of Psychosomatic Research·Paul GrossmanHarald Walach
Mar 5, 2005·Psychiatric Services : a Journal of the American Psychiatric Association·Ruth M Benca
Jun 14, 2005·Clinical Psychology Review·Jack D Edinger, Melanie K Means
Jun 15, 2005·Clinical Psychology Review·Richard R Bootzin, Sally J Stevens
Jul 15, 2005·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Mary Jo KreitzerCharoen Treesak
Nov 3, 2005·International Journal of Behavioral Medicine·Linda E Carlson, Sheila N Garland
Apr 26, 2006·Psychotherapy and Psychosomatics·Thomas HeidenreichJohannes Michalak
Sep 1, 2007·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Ruth LindquistCynthia R Gross
Nov 17, 2007·Explore : the Journal of Science and Healing·Nicole Y WinbushMary Jo Kreitzer
Jun 17, 2008·The Journal of Nervous and Mental Disease·Keunyoung YookMyo-Jung Kim
Dec 31, 2008·Explore : the Journal of Science and Healing·Jason C OngRachel Manber
May 21, 2009·JAMA : the Journal of the American Medical Association·Charles M MorinLucie Baillargeon
Feb 24, 2015·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Jack D EdingerTimothy I Morgenthaler

❮ Previous
Next ❯


Mar 30, 2013·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Taehwan ParkCynthia R Gross
May 29, 2012·BMC Family Practice·Matthew D MitchellCraig A Umscheid
Dec 18, 2012·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Suzanne M BertischEllen P McCarthy
Feb 12, 2014·BMC Complementary and Alternative Medicine·Amber HubblingCynthia R Gross
Oct 12, 2013·Journal of General Internal Medicine·Ruth TamratMadhav Goyal
Jul 6, 2014·Journal of Occupational and Environmental Medicine·Kimberly A AikensCatherine M Bodnar
Oct 27, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Maulik P PurohitRussell S Phillips
Sep 15, 2012·Behaviour Research and Therapy·Jason C OngRachel Manber
Mar 24, 2015·Infant Mental Health Journal·Koa Whittingham, Pamela Douglas
Nov 22, 2013·Journal of the American Association of Nurse Practitioners·Jo Lynne W RobinsNancy L McCain
Jan 1, 2014·Annals of the New York Academy of Sciences·Willoughby B BrittonRoberta E Goldman
Sep 12, 2015·Seminars in Nephrology·Anett V LindnerIstvan Mucsi
Mar 31, 2015·Current Pain and Headache Reports·Todd A SmithermanSutapa G Ford
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Rachel NeuendorfBarry S Oken
Feb 7, 2014·Journal of American College Health : J of ACH·Jeffrey M GreesonHolly Rogers
Sep 25, 2016·Journal of Psychosomatic Research·Hong GongChun-Lei Jiang
Aug 17, 2016·Journal of Behavior Therapy and Experimental Psychiatry·Sarah GrezellschakStefan Westermann
Dec 29, 2016·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Elizabeth AdlerFrederick M Hecht
Jan 8, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sheila N GarlandTavis S Campbell
Aug 12, 2016·Journal of Applied Gerontology : the Official Journal of the Southern Gerontological Society·Autumn M GallegosWilfred R Pigeon
Feb 8, 2014·Holistic Nursing Practice·Alberto ChiesaAlessandro Serretti
Oct 1, 2015·The Australian and New Zealand Journal of Psychiatry·Marie CroweShirley Harris
May 23, 2018·Menopause : the Journal of the North American Menopause Society·Marcelo C GarciaHelena Hachul
Oct 17, 2012·The Gerontologist·Robin R WhitebirdChris J Enstad
Nov 2, 2018·Behavioral Sleep Medicine·Yuan-Yuan WangYu-Tao Xiang

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.