Mindfulness-based therapy for drug-resistant epilepsy: An assessor-blinded randomized trial

Neurology
Venus TangPatrick Kwan

Abstract

To investigate the effectiveness of mindfulness-based therapy (MT) and social support (SS) in patients with drug-resistant epilepsy. We performed an assessor-blinded randomized control trial. Sixty patients with drug-resistant epilepsy were randomly allocated to MT or SS (30 per group). Each group received 4 biweekly intervention sessions. The primary outcome was the change in the total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Secondary outcomes included seizure frequency, mood symptoms, and neurocognitive functions. The assessors were blinded to the patient's intervention grouping. Results were analyzed using general linear model with repeated measure. Following intervention, both the MT (n=30) and SS (n=30) groups had an improved total QOLIE-31-P, with an improvement of +6.23 for MT (95% confidence interval [CI] +4.22 to +10.40) and +3.30 for SS (95% CI +1.03 to +5.58). Significantly more patients in the MT group had a clinically important improvement in QOLIE-31-P (+11.8 or above) compared to those who received SS (11 patients vs 4 patients). Significantly greater reduction in depressive and anxiety symptoms, seizure frequency, and improvement in delayed memory was observed in the MT ...Continue Reading

References

Oct 18, 2000·Seizure : the Journal of the British Epilepsy Association·R GillhamK Kane
Jul 18, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·S WiebeP A Derry
Jul 29, 2003·Psychosomatic Medicine·Richard J DavidsonJohn F Sheridan
Oct 12, 2005·Annals of Neurology·Dale C HesdorfferOlafur Kjartansson
Nov 8, 2005·Neuroreport·Sara W LazarBruce Fischl
Oct 2, 2007·Clinical Psychology Review·Stefan G Hofmann, Gordon J G Asmundson
Mar 18, 2008·Epilepsy & Behavior : E&B·Tobias LundgrenLennart Melin
Jul 28, 2009·Clinical Psychology Review·Richard ChambersNicholas B Allen
Mar 31, 2010·Journal of Consulting and Clinical Psychology·Stefan G HofmannDiana Oh
Jul 6, 2010·The Psychiatric Clinics of North America·Stefan G HofmannAngela Fang
Nov 13, 2010·Psychiatry Research·Britta K HölzelSara W Lazar
Dec 25, 2010·Clinical Psychology Review·Alberto ChiesaAlessandro Serretti
Jan 20, 2011·Journal of Paediatrics and Child Health·Claire K FrizzellAnn M E Bye
Jan 27, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Alberto Chiesa, Alessandro Serretti
Oct 27, 2012·Epilepsy & Behavior : E&B·Nigel C Jones, Terence J O'Brien
Mar 30, 2013·Psychological Science·Michael D MrazekJonathan W Schooler
Jan 15, 2014·Epilepsy & Behavior : E&B·Venus TangPatrick Kwan
Nov 1, 2011·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Britta K HölzelUlrich Ott

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Citations

Jan 19, 2016·Epilepsy & Behavior : E&B·Iliana KotwasJean-Arthur Micoulaud-Franchi
Jan 12, 2016·Consciousness and Cognition·Jordi ManuelloFranco Cauda
Sep 4, 2015·Neurology·Andres M Kanner, Kimford J Meador
Sep 30, 2015·Neurology·Steven D Shapiro, Steven Karceski
Aug 2, 2016·Journal of Psychosocial Nursing and Mental Health Services·Lois M PlattRonald L Koch
Sep 2, 2016·Epilepsy Currents·Mohamad Koubeissi
Nov 12, 2016·Seizure : the Journal of the British Epilepsy Association·Christian E ElgerChristian Hoppe
Mar 5, 2016·Practical Neurology·Clare M GaltreyHannah R Cock
Oct 28, 2017·The Cochrane Database of Systematic Reviews·Rosa MichaelisMarkus Reuber
Jun 26, 2018·The Clinical Neuropsychologist·Siew-Tim LaiVenus Tang
Jan 30, 2019·Current Opinion in Neurology·Sheryl R HautMichael Privitera
Apr 5, 2019·Expert Opinion on Drug Safety·Sameer Sharma, Patrick Kwan
May 1, 2019·Current Psychiatry Reports·Coraline HingrayJean-Arthur Micoulaud-Franchi
Oct 28, 2019·Neurology·Michael PriviteraSusannah Cornes
Apr 7, 2017·Current Neurology and Neuroscience Reports·Beth A Leeman-Markowski, Steven C Schachter
Mar 23, 2017·BMC Neurology·Karen WoodStewart W Mercer
Apr 30, 2019·Human Brain Mapping·Adam M GoodmanJerzy P Szaflarski
Sep 27, 2018·Epilepsy Currents·M Scott Perry
May 5, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Adam M Goodman, Jerzy P Szaflarski
Jun 4, 2021·Epilepsia·Colin B JosephsonUNKNOWN Calgary Comprehensive Epilepsy Program collaborators
Jul 22, 2021·Neuropsychiatric Disease and Treatment·Deborah Guery, Sylvain Rheims

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