Mindin regulates vascular smooth muscle cell phenotype and prevents neointima formation

Clinical Science
Li-Hua ZhuHongliang Li

Abstract

Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in the regulation of inflammatory responses, angiogenesis and metabolic disorders. Our most recent studies indicated that mindin is largely involved in the initiation and development of cardiac and cerebrovascular diseases [Zhu et al. (2014) J. Hepatol. 60, 1046-1054; Bian et al. (2012) J. Mol. Med. 90, 895-910; Wang et al. (2013) Exp. Neurol. 247, 506-516; Yan et al. (2011) Cardiovasc. Res. 92, 85-94]. However, the regulatory functions of mindin in neointima formation remain unclear. In the present study, mindin expression was significantly down-regulated in platelet-derived growth factor-BB (PDGF-BB)-stimulated vascular smooth muscle cells (VSMCs) and wire injury-stimulated vascular tissue. Using a gain-of-function approach, overexpression of mindin in VSMCs exhibited strong anti-proliferative and anti-migratory effects on VSMCs, whereas significant suppression of intimal hyperplasia was observed in transgenic (TG) mice expressing mindin specifically in smooth muscle cells (SMCs). These mice exhibited blunted VSMC proliferation, migration and phenotypic switching. Conversely, dele...Continue Reading

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Citations

Jul 15, 2015·Journal of Hepatology·Peng SunHongliang Li
Sep 29, 2017·Physiological Reviews·Patrick LacolleyStéphane Laurent
Jun 17, 2015·Hypertension·Xiao-Jing ZhangHongliang Li
Aug 8, 2018·The Journal of Physiological Sciences : JPS·Yuko KatoYoshihiro Ishikawa
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May 28, 2020·International Journal of Molecular Sciences·Eva AndreuzziMaurizio Mongiat
May 18, 2020·Biochimica Et Biophysica Acta. General Subjects·Yoko InaiYoshito Ihara

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