Mineralocorticoid antagonism enhances brown adipose tissue function in humans: A randomized placebo-controlled cross-over study

Diabetes, Obesity & Metabolism
Moe ThuzarKen K Y Ho

Abstract

To investigate whether mineralocorticoid (MC) antagonism enhances brown adipose tissue (BAT) function in humans. In a randomized double-blind, cross-over designed trial, 10 healthy adults (two men, eight women) underwent 2 weeks of spironolactone (100 mg/d) treatment and placebo, with an intervening 2-week wash-out period. BAT function was assessed in response to cooling and to a mixed meal. Metabolic activity was measured by fluoro-deoxyglucose (FDG) uptake (maximal standardized uptake value, SUVmax ) using PET-CT. Thermogenic activity was measured by skin temperatures overlying supraclavicular (SCL) BAT depots using infrared thermography. Postprandial metabolism was measured by energy production rate (EPR) and lipid synthesis using indirect calorimetry. During cooling, BAT metabolic activity (SUV 6.30 ± 2.16 vs 3.98 ± 1.34; P < 0.05) and volume (54.9 ± 22.8 vs 21.6 ± 11.8 cm3 ; P < 0.05) were significantly higher, and mean SCL temperature decreased by a smaller degree (-0.3°C°± 0.2°C vs -0.9°C ± 0.2°C; P = 0.05) with spironolactone treatment. A mixed meal increased SCL temperature and EPR. The postprandial rise in SCL temperature (+0.4°C ± 0.1°C vs +0.1°C ± 0.1°C; P < 0.05) but not in EPR was greater during spironolactone tre...Continue Reading

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Citations

Oct 31, 2019·Pediatric Obesity·Lourdes Ibáñez, Francis de Zegher
Sep 30, 2019·Gut·Madhusudan GroverVincenzo Stanghellini
Jul 31, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Vincenzo MarzollaMassimiliano Caprio
Jun 6, 2019·American Journal of Human Biology : the Official Journal of the Human Biology Council·Stephanie B Levy
Jun 17, 2020·Expert Opinion on Investigational Drugs·Luigi Della CortePierluigi Giampaolino
May 1, 2020·Frontiers in Endocrinology·Ruping PanYong Chen
Apr 29, 2020·Journal of the Endocrine Society·Lourdes IbáñezFrancis de Zegher
Jun 9, 2020·Frontiers in Endocrinology·Takafumi HamaokaYuko Kurosawa
Feb 3, 2021·Journal of Human Hypertension·Moe Thuzar, Michael Stowasser
May 1, 2021·Frontiers in Endocrinology·Kasiphak KaikaewJenny A Visser
Sep 18, 2021·Anaesthesia Critical Care & Pain Medicine·Victoria A EleyAndré A van Zundert

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