PMID: 8941013Dec 1, 1996Paper

Mineralocorticoid insufficiency due to suramin therapy

Cancer
K KobayashiM J Ratain

Abstract

During a Phase I trial of suramin, a novel antineoplastic agent with activity against hormone-refractory prostate carcinoma, the authors observed two patients with clinical mineralocorticoid insufficiency in spite of hydrocortisone replacement therapy. The authors retrospectively assessed adrenal cortical function in 20 such patients via adrenocorticotropic stimulation testing, measuring both cortisol and aldosterone responses, either at the time or treatment of immediately after discontinuation of treatment. Two of 9 patients (22%) treated at relatively low dose levels (< or = 1200 mg/m2 on Day 1) demonstrated adrenal cortical insufficiency, as compared with 9 of 11 patients (32%) treated with relatively high doses (> 1200 mg/m2 on Day 1) (P = 0.03 by 1-tailed Fisher's exact test). There appeared to be a cumulative dose-response relationship to the development of glucocorticoid insufficiency, with no instances being observed at doses < 4.8 g/m2 and uniform toxicity occurring at doses > 7.6 g/m2. Long term glucocorticoid insufficiency was present in 1 of 5 patients (20%) tested at an interval of > 90 days after discontinuation of suramin treatment. All instances of glucocorticoid insufficiency were associated with mineralocorti...Continue Reading

References

Jan 1, 1975·Acta Medica Scandinavica·P W KloppenborgC L Majoor
Dec 2, 1978·Lancet·J Prior, I White
Apr 1, 1991·Antimicrobial Agents and Chemotherapy·P K SharkeyJ R Graybill
Feb 1, 1992·Southern Medical Journal·B C Mirtsching, D A Freeman
Aug 20, 1990·Molecular and Cellular Endocrinology·H F MarzoukS W Lamberts
Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·H AshbyB D Albertson
Oct 1, 1989·Statistics in Medicine·L Kaiser
Mar 1, 1989·Tubercle·E G WilkinsA Cope
Jul 1, 1987·The Journal of Clinical Endocrinology and Metabolism·P FeuillanG P Chrousos
Feb 1, 1986·Annals of Internal Medicine·C A SteinE P Gelmann
Apr 26, 1985·JAMA : the Journal of the American Medical Association·W S TuckerC R Gregg
Sep 7, 1974·Lancet·O M EdwardsA D Tait
Jun 1, 1974·Annals of Internal Medicine·R G DluhyM Greenfield
Nov 21, 1981·Lancet·P D WardG MacGregor
May 31, 1984·The New England Journal of Medicine·R L WagnerD Feldman
Jan 1, 1983·The Journal of Clinical Endocrinology and Metabolism·R O'KellyT J McKenna
Jun 11, 1983·British Medical Journal·S DuxJ B Rosenfeld
Jun 11, 1983·British Medical Journal·E H Elansary, J E Earis
Aug 1, 1984·Archives of Internal Medicine·D Brohee, P Neve
Dec 1, 1984·The Journal of Clinical Endocrinology and Metabolism·V KyriazopoulouA G Vagenakis
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M A EisenbergerS C Jacobs
Sep 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K KobayashiM J Ratain
Jan 1, 1995·Transactions of the Royal Society of Tropical Medicine and Hygiene·C HeppnerM Reincke
Feb 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·M ZenattiB Aupetit-Faisant
Sep 16, 1950·British Medical Journal·L J MAHONEY, H J BARRIE
Aug 1, 1984·Archives of Internal Medicine·Russell Hull, Jack Hirsh

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Citations

Jul 18, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A Villalona-CaleroJ L-S Au
Dec 24, 2003·Cancer·Nicholas J VogelzangEverett E Vokes
Nov 10, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Ralph D SandersonThomas Kelly
Nov 7, 1998·Cancer Treatment Reviews·A J Dowling, I F Tannock
Feb 17, 2006·Current Urology Reports·Ravi Munver, Ilya A Volfson
Jul 24, 2008·Journal of Cancer Survivorship : Research and Practice·Charles J StavaRena Vassilopoulou-Sellin
Nov 13, 2013·Journal of the American Animal Hospital Association·Francisco J AlvarezGuillermo Couto

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