PMID: 18729003Aug 30, 2008Paper

Mineralocorticoid receptor antagonists and endothelial function.

Current Opinion in Investigational Drugs
Bradley A Maron, Jane A Leopold

Abstract

Hyperaldosteronism is associated with endothelial dysfunction and impaired vascular reactivity in patients with hypertension or congestive heart failure. When present, endothelial dysfunction is an independent predictor of adverse cardiovascular events. The mineralocorticoid receptor (MR) antagonists spironolactone and eplerenone reduce morbidity and mortality, and it has been suggested that this occurs, in part, as a result of improved vascular function. The routine use of MR antagonists in patients with cardiovascular disease, however, is limited by the development of gynecomastia with spironolactone use and hyperkalemia with the use of both agents. Therefore, the development of newer agents with more favorable side-effect profiles is needed.

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Related Papers

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Todd R Marcy, Toni L Ripley
Current Hypertension Reports
William H Frishman, Charles T Stier
© 2022 Meta ULC. All rights reserved