Mineralocorticoid receptor associates with pro-inflammatory bias in the hippocampus of spontaneously hypertensive rats

Journal of Neuroendocrinology
Maria Elvira BroccaAlejandro F De Nicola

Abstract

Damage observed in the hippocampus of the adult spontaneously hypertensive rat (SHR) resembles the neuropathology of mineralocorticoid-induced hypertension, supporting a similar endocrine dysfunction in both entities. In the present study, we tested the hypothesis that increased expression of the hippocampal mineralocorticoid receptor (MR) in SHR animals is associated with a prevalent expression of pro-inflammatory over anti-inflammatory factors. Accordingly, in the hippocampus, we measured mRNA expression and immunoreactivity of the MR and glucocorticoid receptor (GR) using a quantitative polymerase chain reaction and histochemistry. We also measured serum-glucocorticoid-activated kinase 1 (Sgk1 mRNA), the number and phenotype of Iba1+ microglia, as well as mRNA expression levels of the pro-inflammatory factors cyclo-oxygenase 2 (Cox2), Nlrp3 inflammasome and tumour necrosis factor α (Tnfα). Expression of anti-inflammatory transforming growth factor (Tgf)β mRNA and the NADPH-diaphorase activity of nitric oxide synthase (NOS) were also determined. The results showed that, in the hippocampus of SHR rats, expression of MR and the number of immunoreactive MR/GR co-expressing cells were increased compared to Wistar-Kyoto control an...Continue Reading

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Citations

Nov 23, 2017·Metabolic Brain Disease·Titikorn ChunchaiSiriporn C Chattipakorn
Dec 24, 2018·Journal of Neuroendocrinology·Edo R de KloetAnnette D de Kloet
Mar 16, 2021·Frontiers in Endocrinology·Hélène Duez, Benoit Pourcet
Nov 2, 2019·Neuroscience and Biobehavioral Reviews·Erik H Douma, E Ronald de Kloet
Jun 18, 2021·American Journal of Hypertension·Jessica Youwakim, Hélène Girouard

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