PMID: 16529552Mar 15, 2006Paper

Mineralocorticoid receptor blockade in the protection of target organ damage

Cardiovascular & Hematological Agents in Medicinal Chemistry
Paolo MulateroFranco Veglio

Abstract

Over the last decade a wealth of studies have shed new light on the role of aldosterone in the pathogenesis of cardiovascular diseases. It is now evident that in addition to its classical role in increasing sodium re-absorbtion in the kidney , aldosterone also exhibits several nonepithelial effects such as the induction of inflammation, fibrosis and necrosis in various organs. Herein we review the experimental evidences for the protective effects of mineralocorticoid receptor blockade in the prevention and treatment of target organ damage, both in animals and in humans. We also discuss the pharmacological and clinical differences between the two available mineralocorticoid receptor blockers, spironolactone and eplerenone.

Citations

Feb 1, 2011·Reviews in Endocrine & Metabolic Disorders·Paolo MulateroFranco Veglio
May 16, 2009·Current Hypertension Reports·Paolo MulateroFranco Veglio
Sep 23, 2014·Molecular and Cellular Endocrinology·Silvia MonticoneWilliam E Rainey
Apr 17, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Frank KramerThomas Krahn
Dec 28, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Andreas TomaschitzWinfried März
Apr 16, 2008·Clinical Endocrinology·Andrea VerhovezPaolo Mulatero
Jun 19, 2007·Clinical Endocrinology·Paolo MulateroFranco Veglio
Jan 27, 2015·Clinical Biochemistry·Muhammad RehanDaniel T Holmes
Dec 30, 2014·European Journal of Endocrinology·George PiaditisGregory Kaltsas
Apr 28, 2017·Journal of Human Hypertension·S MonticoneP Mulatero
Nov 4, 2006·Journal of Hypertension·Simona MauleFranco Veglio
Feb 27, 2019·Drugs·Sean Duggan
May 26, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Mara MedeirosNorma A Bobadilla
Dec 24, 2019·Cardiology in Review·Padma Raghavan PillaiIrene A Weiss
Apr 15, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Paolo MulateroFranco Veglio
Feb 25, 2006·Endocrinology·Tracy A WilliamsPaolo Mulatero
Jan 17, 2008·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroFranco Veglio
Aug 15, 2014·The Journal of Clinical Endocrinology and Metabolism·Silvia MonticonePaolo Mulatero
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Adina F Turcu, Richard Auchus
Oct 2, 2021·Expert Opinion on Investigational Drugs·Bertram PittGeorge Bakris

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