Mineralocorticoid receptor function and cognition in health and disease

Psychoneuroendocrinology
Katja Wingenfeld, Christian Otte

Abstract

The steroid hormone cortisol is released in response to stress and exerts its effects in the brain via two different receptors: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR). This review - dedicated to Dirk Hellhammer - focusses on the role of MR on cognitive and emotional function in healthy individuals and in stress-associated disorders such as major depressive disorder (MDD) or borderline personality disorder (BPD). Animal data and studies from healthy individuals converge such that MR play an important role in the appraisal of new situations and the following response selection. Decision-making and empathy are important determinants of this response selection and both are affected by MR function. Furthermore, MR are crucially involved in visuospatial navigation and memory in young and elderly healthy individuals whereas the exact physiological role of MR in verbal learning and verbal memory needs to be further characterized. In contrast to studies in healthy participants, age played a moderating role on the effects of MR stimulation on cognition in depressed patients. In young depressed patients, MR stimulation exerted beneficial effects on verbal memory and executive function, whereas in elderly ...Continue Reading

Citations

Jul 16, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Nadezhda D Goncharova
Aug 24, 2019·Frontiers in Behavioral Neuroscience·Valeria BonapersonaRatna Angela Sarabdjitsingh
Feb 13, 2020·Frontiers in Psychiatry·Agorastos AgorastosPanagiota Pervanidou
Sep 15, 2020·Frontiers in Neuroscience·Asuka Matsuzaki TadaIkuo Tooyama
Jul 30, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jan NowackiChristian Otte
Jan 9, 2021·Psychoneuroendocrinology·Nefize YalinPaul Ra Stokes
Feb 6, 2021·Cellular and Molecular Neurobiology·Serpil TaheriFahrettin Kelestimur
Feb 9, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gesa BerretzSebastian Ocklenburg
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Nov 24, 2021·British Journal of Pharmacology·Claudia GrossmannDiego Alvarez de la Rosa
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