Mineralocorticoid receptor is involved in the regulation of genes responsible for hepatic glucose production

Biochemical and Biophysical Research Communications
Guohong LiuQi-Xiang Li

Abstract

The mineralocorticoid receptor (MR) is expressed in kidney and plays a central role in the control of sodium, homeostatic fluid, and blood pressure. It has also been implicated in other functions in cardiovascular system, central nervous system, and adipose tissue. This study revealed a novel role of MR in the gene regulation related to hepatic glucose production. RNAi-mediated MR silencing led to a decrease in the expression of glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase, and fructose-1,6-bisphosphatase 1, the enzymes known to be involved in glucose production in liver. The MR-specific antagonists also down-regulated the expression of G6Pase, while the specific agonist enhanced G6Pase expression. These observations, for the first time, revealed a novel role for MR and its ligands in the regulation of de novo glucose synthesis in hepatocytes. It also suggests the potential of liver-specific MR modulation for the treatment of hyperglycemia.

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Citations

Sep 13, 2011·The Canadian Journal of Cardiology·Valerie Bassien-CapsaAlzbeta Chorvatova
Oct 6, 2009·Trends in Endocrinology and Metabolism : TEM·Maria-Christina ZennaroBruno Fève
Sep 18, 2007·Seminars in Nephrology·Bruno VogtMichel Burnier
Aug 18, 2006·Molecular Aspects of Medicine·Paolo AscenziMaria Marino
Mar 13, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Atsuhisa Sato
Mar 28, 2009·American Journal of Hypertension·Fernando MartinezFelipe J Chaves
Sep 30, 2016·Journal of the American Heart Association·Rene BaudrandLuminita H Pojoga
Nov 3, 2020·Frontiers in Endocrinology·Stine M PræstholmLars Grøntved

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