PMID: 8603039Jan 1, 1996Paper

Mineralocorticoid receptors in the central nervous system

The Journal of Steroid Biochemistry and Molecular Biology
John W Funder

Abstract

"Mineralocorticoid receptors (MR) in the central nervous system" is something of a misnomer, in that the sites so designated almost certainly act predominantly as high affinity receptors for glucocorticoid hormones in most areas of the brain, reflecting the equivalent affinity of MR for aldosterone, corticosterone and cortisol. In epithelial tissues, the enzyme 11 beta hydroxysteroid dehydrogenase-2 confers aldosterone-specificity on the otherwise non-selective MR, by converting physiologic glucocorticoids (but not aldosterone) to receptor-inactive 11-keto metabolites. Coding differences in guinea-pig ACTH and glucocorticoid receptors produce very high circulating free cortisol levels; guinea-pig MR have nonetheless similar high affinity for aldosterone and glucocorticoids as those in the rat, evidence for the lack of evolutionary drive towards lower affinity MR, and for an "always occupied" mode of action of CNS MR. Whether these "always occupied" MR act at composite response elements, by the formation of heterodimers with GR or other transcription factors, or by binding progesterone in the luteal phase, in pregnancy and in utero, remains to be established.

References

Feb 1, 1976·The Australian Journal of Experimental Biology and Medical Science·G T WhippB A Scoggins
Nov 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J W FunderL P Roy
Jan 1, 1986·Neuroendocrinology·B S McEwenA F De Nicola
Feb 1, 1972·Journal of Steroid Biochemistry·G RousseauG M Tomkins
May 1, 1973·Endocrinology·D FeldmanI S Edelman
Feb 1, 1972·Journal of Steroid Biochemistry·J W FunderI S Edelman
Aug 24, 1972·The New England Journal of Medicine·H N Claman
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·Z S Krozowski, J W Funder
Jun 1, 1995·Molecular and Cellular Endocrinology·K Yang, S G Matthews
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski

❮ Previous
Next ❯

Citations

Apr 2, 1998·Progress in Neurobiology·K M MacLennanC L Darlington
Mar 4, 1998·Molecular and Cellular Endocrinology·M E Baker
Dec 23, 2003·Best Practice & Research. Clinical Endocrinology & Metabolism·Paolo Ferrari
Apr 12, 2000·Kidney International·P Ferrari, Z Krozowski
Mar 22, 2000·Journal of Hypertension·P FerrariF J Frey
May 16, 2002·Reviews in the Neurosciences·Nuno Sousa, Osborne F X Almeida
Jul 13, 2000·General and Comparative Endocrinology·M OrchinikP J Gasser
Oct 16, 2015·Molecular Medicine Reports·Kenroh Sasaki, Fumihiko Yoshizaki
Dec 17, 2008·Seminars in Fetal & Neonatal Medicine·Ana Raquel MesquitaOsborne F X Almeida
Jan 20, 2006·The European Journal of Neuroscience·Eliane ProulxJose L Perez Velazquez
Dec 15, 2010·Frontiers in Neuroendocrinology·Caitlin S WyrwollJonathan R Seckl
Mar 4, 2015·Neuroscience Bulletin·Phillipe Leff GelmanJuan Pablo Reyes Grajeda
Nov 17, 2009·Biochimica Et Biophysica Acta·Paolo Ferrari

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.