Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

Bioinformatics
Martin J AryeeRafael A Irizarry

Abstract

The recently released Infinium HumanMethylation450 array (the '450k' array) provides a high-throughput assay to quantify DNA methylation (DNAm) at ∼450 000 loci across a range of genomic features. Although less comprehensive than high-throughput sequencing-based techniques, this product is more cost-effective and promises to be the most widely used DNAm high-throughput measurement technology over the next several years. Here we describe a suite of computational tools that incorporate state-of-the-art statistical techniques for the analysis of DNAm data. The software is structured to easily adapt to future versions of the technology. We include methods for preprocessing, quality assessment and detection of differentially methylated regions from the kilobase to the megabase scale. We show how our software provides a powerful and flexible development platform for future methods. We also illustrate how our methods empower the technology to make discoveries previously thought to be possible only with sequencing-based methods. http://bioconductor.org/packages/release/bioc/html/minfi.html. khansen@jhsph.edu; rafa@jimmy.harvard.edu Supplementary data are available at Bioinformatics online.

References

Jul 20, 1987·Journal of Molecular Biology·M Gardiner-Garden, M Frommer
Jan 21, 2004·Nature Reviews. Cancer·Andrew P Feinberg, Benjamin Tycko
May 25, 2007·Nature·Andrew P Feinberg
Mar 5, 2008·Genome Research·Rafael A IrizarryAndrew P Feinberg
Jan 26, 2010·Biostatistics·Matthew N McCallRafael A Irizarry
Sep 15, 2010·Nature Reviews. Genetics·Jeffrey T LeekRafael A Irizarry
Sep 23, 2010·Biostatistics·Martin J AryeeRafael A Irizarry
Oct 27, 2010·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Zhijin Wu, Martin J Aryee
May 10, 2011·BMC Bioinformatics·Matthew N McCallRafael A Irizarry
Jun 28, 2011·Nature Genetics·Kasper D HansenAndrew P Feinberg
Jul 13, 2011·Nature Reviews. Genetics·V RakyanStephan Beck
Aug 16, 2011·Genomics·Marina BibikovaRichard Shen
Feb 1, 2012·Nature Methods·Felix KruegerSimon R Andrews
Mar 17, 2012·International Journal of Epidemiology·Andrew E JaffeRafael A Irizarry
Jul 10, 2012·Cell·Mark A Dawson, Tony Kouzarides
Sep 1, 2012·Frontiers in Genetics·Frank Wessely, Richard D Emes
Nov 28, 2012·Molecular Cell·Gregory HannumKang Zhang
Feb 21, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Francesco MarabitaDavid Gomez-Cabrero
Mar 12, 2013·Nucleic Acids Research·Timothy J TricheKimberly Siegmund
May 2, 2013·BMC Genomics·Ruth PidsleyLeonard C Schalkwyk
Jul 3, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Degui ZhiDonna K Arnett
Aug 21, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Paul YousefiNina Holland

Citations

Feb 15, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Raul A Chavez ValenciaJustine Ellis
Jul 24, 2014·Neuromolecular Medicine·Makoto KinoshitaTetsuro Ohmori
Aug 26, 2014·Bioinformatics·Maarten van ItersonBastiaan T Heijmans
Sep 30, 2014·Nature Methods·Yassen AssenovChristoph Bock
Dec 22, 2015·Neuron·BrainSeq: A Human Brain Genomics Consortium. Electronic address: drweinberger@libd.org, BrainSeq: A Human Brain Genomics Consortium
Apr 15, 2016·EBioMedicine·Yinan ZhengLifang Hou
Feb 9, 2016·Statistical Applications in Genetics and Molecular Biology·Shuying Sun, Xiaoqing Yu
Oct 17, 2015·American Journal of Respiratory and Critical Care Medicine·Jessie Nicodemus-JohnsonCarole Ober
Feb 11, 2016·Nature Communications·Bonnie R JoubertStephanie J London
Jul 15, 2015·American Journal of Human Genetics·Emma StrongLucy R Osborne
Mar 13, 2016·Seminars in Oncology·Daoud MeerzamanSharon Ross
Feb 2, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Sergi Sayols-BaixerasRoberto Elosua
Feb 3, 2016·Annals of Human Genetics·Mubo ChenQihua Tan
Jan 30, 2016·Nature Communications·Andrew E TeschendorffMartin Widschwendter
Dec 9, 2015·Human Molecular Genetics·Carolina Soriano-TárragaGENESTROKE Consortium
Jan 30, 2016·Clinical Epigenetics·Wadha A Al MuftahKarsten Suhre
Dec 10, 2015·Epigenetics : Official Journal of the DNA Methylation Society·R C HuangKaren Lillycrop
Mar 24, 2016·Journal of Immunology Research·R Alan HarrisRichard Kellermayer
Jan 9, 2016·Acta Neuropathologica·Alberto BroniscerBrent A Orr
Jan 14, 2016·Clinical Epigenetics·Merli SaareMaire Peters
Jan 20, 2016·Journal of Autoimmunity·Emon ElboudwarejJanelle A Noble
Jan 2, 2016·American Journal of Epidemiology·Huihuang YanTamas Ordog
Dec 1, 2015·Nature Neuroscience·Eilis HannonJonathan Mill
Oct 1, 2015·Journal of Crohn's & Colitis·Edel McDermottTherese M Murphy
Oct 9, 2015·Psychoneuroendocrinology·Erika J WolfMark W Miller
Dec 23, 2015·Scandinavian Journal of Rheumatology·A P WebsterD Plant
Nov 14, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Pei-Chien TsaiJordana T Bell
Nov 4, 2015·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Shuai LiJohn L Hopper
Jul 17, 2015·Epigenomics·Benjamin I LauferShiva M Singh
Mar 10, 2016·BMC Bioinformatics·Devin C KoestlerKarl T Kelsey
Nov 27, 2015·Environmental Research·Christine Ladd-AcostaM Daniele Fallin
Sep 4, 2015·Environmental and Molecular Mutagenesis·Paul YousefiNina Holland
Mar 12, 2016·Epigenetics : Official Journal of the DNA Methylation Society·John K WienckeKarl T Kelsey
Jul 23, 2015·Nature·Xose S PuenteElías Campo
Aug 4, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Alem S GabrielGordon Strathdee
Jan 31, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Robert LoweV Rakyan
Mar 25, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Catherine AllardMarie-France Hivert
Jun 4, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Ting Ting WangWei Chen
Jun 6, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Arko SenDouglas M Ruden
Dec 9, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Divya ChhabraDawn L DeMeo
Dec 9, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Manori AmarasekeraSusan Prescott
Mar 29, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Kelly M BakulskiM Daniele Fallin
Sep 12, 2015·Fertility and Sterility·Kenneth I AstonDouglas T Carrell
Nov 18, 2015·Translational Psychiatry·L F WocknerJ Voisey
Jul 11, 2015·BMC Bioinformatics·Dongmei LiTimothy Dye
Apr 5, 2016·American Journal of Human Genetics·Bonnie R JoubertStephanie J London
Apr 12, 2015·International Journal of Epidemiology·Leanne K KüpersHarold Snieder
Apr 17, 2015·International Journal of Epidemiology·Jason I FeinbergAndrew P Feinberg
May 21, 2015·International Journal of Epidemiology·Caroline L ReltonGeorge Davey Smith
Apr 9, 2016·Environment International·Samantha L KingsleyGregory A Wellenius
Apr 8, 2016·Nature Communications·Jenny van DongenDorret I Boomsma
May 13, 2015·Biostatistics·Kwame Okrah, Héctor Corrada Bravo
Jun 26, 2015·Stem Cells·Galbha DuggalBjörn Heindryckx
Aug 27, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sjur ReppeKaare M Gautvik
May 20, 2015·Molecular Reproduction and Development·Emily S WanDawn L DeMeo
Sep 4, 2015·BMC Bioinformatics·Florin Chelaru, Héctor Corrada Bravo
Jun 5, 2015·Genome Biology·Stephanie C Hicks, Rafael A Irizarry
Mar 15, 2015·The Journal of Allergy and Clinical Immunology·Ivana V YangDavid A Schwartz
Jun 9, 2015·Nature Genetics·Marta KulisJose I Martin-Subero
Jun 27, 2015·Biology of Sex Differences·Masatoshi InoshitaTetsuro Ohmori
Jan 30, 2015·Genome Biology·Olivier GevaertSylvia K Plevritis
Jan 31, 2015·Genome Biology·Riccardo E MarioniIan J Deary
May 20, 2015·Clinical Epigenetics·Adrian Ruiz-HernandezMaria Tellez-Plaza
Feb 14, 2015·The Journal of Allergy and Clinical Immunology·David MartinoHealthNuts Study Investigators
Apr 26, 2014·Epigenetics : Official Journal of the DNA Methylation Society·David MartinoSusan Prescott
Jun 18, 2014·Epigenetics : Official Journal of the DNA Methylation Society·R Alan HarrisRichard Kellermayer
May 3, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Rafael Guerrero-PrestonDavid Sidransky
Dec 3, 2014·Methods : a Companion to Methods in Enzymology·Lee M Butcher, Stephan Beck
Mar 26, 2015·Frontiers in Genetics·Jonathan A Heiss, Hermann Brenner
Sep 23, 2014·Methods : a Companion to Methods in Enzymology·Tiffany J Morris, Stephan Beck
Apr 23, 2016·BMC Bioinformatics·Andrew E TeschendorffMartin Widschwendter
Mar 26, 2015·Clinical Epigenetics·Travers ChingLana X Garmire
Aug 5, 2014·Nature Methods·Florin ChelaruHéctor Corrada Bravo
Oct 4, 2014·Frontiers in Genetics·Mark D RobinsonXiaobei Zhou
Jan 7, 2015·Endocrine-related Cancer·Charles E MassieAndy G Lynch
Apr 30, 2016·Clinical Epigenetics·Michelle L WrightTimothy P York
May 21, 2016·Briefings in Functional Genomics·Fayou WangXiaoqi Zheng
Jun 2, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Nady El HajjThomas Haaf
Jun 5, 2016·Journal of Translational Medicine·Rocío G UrdinguioEmpar Lurbe
Mar 31, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Tina Bianco-MiottoClaire T Roberts
Jun 10, 2016·Clinical Epigenetics·Andrew Y F Li YimPeter Henneman
Jul 28, 2016·Environmental Epigenetics·Jamaji C Nwanaji-EnweremAndrea A Baccarelli
Jun 22, 2016·Briefings in Functional Genomics·Dao-Peng ChenCathy S J Fann
Jun 24, 2016·BMC Genomics·Jie Liu, Kimberly Siegmund
Oct 23, 2015·PLoS Genetics·Roderick C SliekerSusana M Chuva de Sousa Lopes
Jun 29, 2016·Genome Biology·Koen F DekkersBastiaan T Heijmans
Feb 18, 2016·Arthritis & Rheumatology·Oscar Alvarez-GarciaMartin K Lotz
Jul 2, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Alison G PaquetteCarmen Marsit
Mar 15, 2016·Allergy·Gabrielle A LockettJohn W Holloway
Aug 6, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Kristina GervinRobert Lyle
Aug 12, 2016·Genome Biology·Steve HorvathThemistocles L Assimes
Aug 21, 2016·Bipolar Disorders·Kyle J BurghardtVicki L Ellingrod
Oct 7, 2016·Journal of Psychiatric Research·Annette MilnikVanja Vukojevic
Sep 17, 2016·Nucleic Acids Research·Marie KalwaWolfgang Wagner
Aug 26, 2016·Human Molecular Genetics·Tom G RichardsonTom R Gaunt
Sep 23, 2016·Genome Biology·Roderick C SliekerBastiaan T Heijmans
Oct 1, 2016·Clinical Epigenetics·Mi Kyeong LeeWoo Jin Kim
Oct 11, 2016·Nature Genetics·Sameer AgnihotriGelareh Zadeh
Oct 19, 2016·Biochimica Et Biophysica Acta·Federica ParodiBarbara Banelli
Sep 27, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Andres CardenasMarie-France Hivert
Oct 21, 2016·Epigenomics·Trine B RoungeElisabete Weiderpass
Nov 9, 2016·Journal of the American Society of Nephrology : JASN·Britta E JonesDominic J Ciavatta
Oct 31, 2016·Bioinformatics·Diogo AlmeidaJan Baumbach
Sep 30, 2014·PloS One·Dylan AïssiDavid-Alexandre Trégouët
Aug 26, 2016·PloS One·Ruslan AkulenkoVolkhard Helms
Feb 19, 2015·PLoS Genetics·Tian YuanAndrew E Teschendorff
Jan 10, 2017·Nature Communications·Renea A TaylorRobert G Bristow
Jan 12, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Jinming ZhangDavid C Christiani
Feb 7, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Xiumei HongXiaobin Wang
Jan 18, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Julia SteinbergJeremy Mark Wilkinson
Jan 12, 2017·Human Molecular Genetics·Konrad RawlikAlbert Tenesa
Aug 17, 2016·Scientific Reports·Weihua YueYueqin Huang
Jun 28, 2016·F1000Research·Jovana MaksimovicAlicia Oshlack
Apr 7, 2017·Genome Medicine·Davide Degli EspostiZdenko Herceg
Apr 8, 2017·Scientific Reports·Delphine FradinPierre Bougnères
Apr 8, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Nicholas D JohnsonKaren N Conneely
Apr 14, 2017·Scientific Reports·Alex W HewittRichard Saffery
Jun 10, 2017·Pediatric Blood & Cancer·Simone HettmerMelanie Boerries
May 11, 2017·Nature·Helena KilpinenDaniel J Gaffney
May 10, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jamaji C Nwanaji-EnweremJoel D Schwartz
Jan 10, 2017·Nature Genetics·Simon Papillon-CavanaghNada Jabado
Jul 6, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Jose Ramon Hernandez MoraDavid Monk
Jul 6, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Akpéli V NordorMartin J Aryee
Jun 22, 2017·Environmental Science & Technology·Jamaji C Nwanaji-EnweremJoel D Schwartz
Jun 13, 2017·Bioinformatics·Yu-Jia ShiahPaul C Boutros
Jul 26, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Katharina HeßelbachMatjaz Humar
Oct 5, 2017·Human Molecular Genetics·Alexander J TitusBrock C Christensen
Sep 30, 2017·Bioinformatics·Yuan TianAndrew E Teschendorff
Oct 12, 2017·Journal of Developmental Origins of Health and Disease·D Montoya-WilliamsConnie J Mulligan
Jul 15, 2017·Nutrients·Jessie Nicodemus-Johnson, Robert A Sinnott
Feb 9, 2018·International Journal of Molecular Sciences·Sabrina IqbalWilfried J J Karmaus
Oct 14, 2017·Cerebral Cortex·Stefano NardoneEvan Elliott
Nov 11, 2017·The Journal of Clinical Endocrinology and Metabolism·Cristóbal Bernardo-CastiñeiraMaría-Dolores Chiara
Oct 17, 2017·Biostatistics·Stephanie C HicksHéctor Corrada Bravo
Oct 17, 2017·Nucleic Acids Research·Yehoshua EnukaYosef Yarden
Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Hae Dong WooZdenko Herceg
Mar 22, 2018·Stem Cell Research & Therapy·Srijaya Thekkeparambil ChandraboseShigeki Sugii
Apr 19, 2018·Bioinformatics·Pierre-Louis CedozOlivier Gevaert
Apr 13, 2018·Nature·Sophie F RoerinkHans Clevers
Apr 14, 2018·Genome Research·Ruth PidsleySusan J Clark
Apr 27, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Hagen KlettMelanie Boerries
Nov 28, 2017·Clinical Epigenetics·Lu GaoCarrie V Breton
Mar 22, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Yuet-Kin LeungShuk-Mei Ho
Mar 8, 2018·Nucleic Acids Research·Shannon E EllisJeffrey T Leek
Dec 27, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y M GeurtsRoger L Milne
Jan 10, 2018·Frontiers in Aging Neuroscience·Anna StarnawskaLene Christiansen
Dec 15, 2017·BMC Bioinformatics·Carlos Ruiz-Arenas, Juan R González
Dec 20, 2017·European Journal of Human Genetics : EJHG·Nara SobreiraHans T Bjornsson
Dec 21, 2017·Nature Communications·Elliot StieglitzMignon L Loh
Jan 5, 2018·Clinical Epigenetics·Anneli C S BolundTorben Sigsgaard
Aug 25, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Charleen D AdamsParveen Bhatti
Nov 4, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Sergi Sayols-BaixerasRoberto Elosua
Apr 13, 2018·Molecular Nutrition & Food Research·Li ChenHaidong Zhu
May 16, 2018·American Journal of Epidemiology·Klodian DhanaAbbas Dehghan
Oct 28, 2015·Epigenomics·Christine Ladd-Acosta, M Daniele Fallin
Jun 16, 2018·Environmental Health Perspectives·Jun LiTangchun Wu
May 13, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew R DiNardoGeorge Makedonas
Oct 13, 2017·International Journal of Epidemiology·Janine F FelixStephanie J London
May 18, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Stephanie ShiauLouise Kuhn
Jun 28, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Boyang ZhangXiaobin Wang
Jun 28, 2016·F1000Research·Jovana MaksimovicAlicia Oshlack
Jun 22, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Chongchang ZhouHongxia Deng
Feb 14, 2018·Annals of the Rheumatic Diseases·Juliana Imgenberg-KreuzJohanna K Sandling
Oct 14, 2017·American Journal of Physical Anthropology·Christopher J ClukayConnie J Mulligan
Jul 26, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Olivia SolomonNina Holland
Aug 11, 2018·Genome Research·Masako SuzukiJohn M Greally
Sep 22, 2017·Environmental Health Perspectives·Andres CardenasAndrea A Baccarelli
Feb 8, 2018·Environmental Health Perspectives·Ana Julia de F C LichtenfelsJudith M Vonk
Sep 6, 2018·International Journal of Cancer. Journal International Du Cancer·Liangliang ZhuJing Li
Sep 4, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Anne K BozackMolly L Kile
Sep 21, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Xinyi LinNeerja Karnani
Sep 27, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Li ChenHaidong Zhu
Oct 31, 2017·PloS One·Pooja MandaviyaCHARGE Consortium Epigenetics group and BIOS Consortium
Sep 26, 2015·PLoS Genetics·Anu LoukolaJaakko Kaprio
Jul 8, 2016·Science Advances·Till F M AndlauerBertram Müller-Myhsok
Oct 2, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Ina ZaimiDominique S Michaud
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·Andy MadridReid S Alisch
Oct 24, 2018·Molecular Nutrition & Food Research·Chanachai Sae-LeeHyang-Min Byun
Oct 7, 2014·F1000Research·Jean-Philippe FortinKasper Hansen
Dec 6, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Santiago HerreraPatrick O McGowan
Dec 13, 2018·PloS One·Hanne Sagsveen HjorthaugMonica C Munthe-Kaas
Jan 13, 2016·Environmental Health Perspectives·Xiaoyan ZhuTangchun Wu
Jan 9, 2019·Epigenomics·Edwina H YeungEnrique F Schisterman
Nov 18, 2018·International Journal of Cancer. Journal International Du Cancer·Nikos PapakonstantinouKostas Stamatopoulos
Jan 18, 2019·Statistical Applications in Genetics and Molecular Biology·Samara F KiihlMaria Tellez-Plaza
Feb 7, 2018·Interdisciplinary Sciences, Computational Life Sciences·Agnieszka Cecotka, Joanna Polanska
Feb 19, 2019·Current Environmental Health Reports·Maria Grau-PerezMaria Tellez-Plaza
Feb 22, 2018·Scientific Reports·Claire M RobinsonMichael Ohh
Mar 2, 2018·Nature Communications·Jihoon E JookConFab
Mar 1, 2019·Journal of Neuropathology and Experimental Neurology·Matthew TorreSanda Alexandrescu
Mar 5, 2019·Alcoholism, Clinical and Experimental Research·Yihong ZhaoZhi-Liang Zheng
Apr 4, 2018·Journal of the American Society of Nephrology : JASN·Line HeylenBen Sprangers
Mar 16, 2019·Epigenomics·Jan Maarten CobbenMarcel M A M Mannens
Mar 16, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Adrienne Henderson-SmithPaula Desplats
Mar 16, 2019·Scientific Reports·Janitza L Montalvo-OrtizJoel Gelernter
Feb 27, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Candace R LewisKathryn Lemery-Chalfant
Mar 20, 2019·Translational Psychiatry·Chirag M VyasOlivia I Okereke
Feb 8, 2018·Nature·Zhi-Min ZhangJikui Song
Mar 27, 2019·PloS One·Jin ZhouJefferey L Burgess
Mar 19, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Aaron M MooreJack A Taylor
Feb 17, 2018·Epigenetics : Official Journal of the DNA Methylation Society·John DouKelly M Bakulski
Jul 13, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Pei-Fen KuanPaolo Boffetta
Aug 3, 2018·Development and Psychopathology·Elika GargMavan Study Team
Apr 20, 2019·PloS One·Radhika DhingraCavin K Ward-Caviness
Apr 24, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Jyotirmoy DasMaria Lerm
May 6, 2019·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·David A SbarraMatthias R Mehl
Nov 14, 2017·Nature Reviews. Genetics·Andrew E Teschendorff, Caroline L Relton
Jun 1, 2018·Epigenetics & Chromatin·Roderick C SliekerBastiaan T Heijmans
Sep 12, 2017·Translational Psychiatry·R GuptaAnu Loukola
Feb 21, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Vibe Maria JacobsenQihua Tan
May 11, 2019·The European Respiratory Journal·Medea ImbodenNicole Probst-Hensch
May 24, 2019·Molecular Systems Biology·Jan-Philipp MallmKarsten Rippe
Nov 21, 2018·The British Journal of Psychiatry : the Journal of Mental Science·D MehtaVibe G Frokjaer
Aug 15, 2019·Nucleic Acids Research·Goran JosipovićVlatka Zoldoš
Sep 4, 2019·Translational Psychiatry·Anna StarnawskaLene Christiansen
Aug 30, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Elizabeth M KennedyCarmen Marsit
Jul 28, 2019·Immunology·Candace C LiuAaron M Newman
Jun 13, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Snjezana DoganMatija Snuderl
Aug 5, 2017·BMC Genomics·Behrooz Torabi MoghadamManfred Grabherr
Apr 25, 2018·Database : the Journal of Biological Databases and Curation·Kleanthi LakiotakiIoannis Tsamardinos
Jul 31, 2018·American Journal of Epidemiology·Amanda HughesMeena Kumari
Nov 7, 2018·Scientific Reports·Kirsti KvaløyTurid Lingaas Holmen
Nov 18, 2019·Statistical Applications in Genetics and Molecular Biology·Tobias MadsenJakob Skou Pedersen
Oct 9, 2019·Epigenomics·Eleftheria TheodoropoulouMaja Jagodic
May 22, 2019·Stem Cell Research & Therapy·Stefania TrinoLuciana De Luca
Dec 7, 2019·Science·Tim H H CoorensSam Behjati
Aug 17, 2019·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Mariana L Rodríguez-LópezHumberto Nicolini
Sep 12, 2019·Journal of Cachexia, Sarcopenia and Muscle·Lingxiao HeMartine Thomis
Dec 14, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Kathleen CheungLouise N Reynard
Aug 3, 2019·Nursing Research·Patricia A KinserAngela Starkweather
Aug 3, 2019·Annals of the Rheumatic Diseases·Javier Rodríguez-UbrevaEsteban Ballestar
Oct 5, 2019·Nucleic Acids Research·Zhuang XiongYiming Bao
Nov 2, 2019·Genes·Enrique Hernández-LemusSoledad Ochoa
Oct 12, 2019·Experimental Dermatology·Viktória KoroknaiMargit Balázs
Nov 27, 2019·Acta Neuropathologica·Yi TanThomas Koeglsperger
Jan 31, 2020·PloS One·Nabila KazmiCaroline L Relton
Jan 17, 2020·Human Molecular Genetics·Lucas A SalasBrock C Christensen
Dec 24, 2019·Human Molecular Genetics·Milena N LesevaBarwon Infant Study Investigator Group
Jul 24, 2017·Neurology·Carolina Soriano-TárragaJordi Jiménez-Conde
Jan 28, 2020·Bioinformatics·Evan GatevMichael S Kobor
Dec 5, 2019·Thyroid : Official Journal of the American Thyroid Association·Jong-Lyul ParkYong Sung Kim
Jan 20, 2020·Neuropathology and Applied Neurobiology·E Perez, David Capper
Feb 23, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Boris NovakovicRichard Saffery
Oct 15, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Gary S PittmanDouglas A Bell
Jan 12, 2020·Nucleic Acids Research·Julian A N M HalmaiKyle D Fink
Feb 25, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Kenneth WestermanDawn L DeMeo
Mar 16, 2019·Genome Biology·Fabian MüllerChristoph Bock
Mar 15, 2020·American Journal of Physical Anthropology·Genevieve HousmanAnne C Stone
Feb 9, 2020·Diabetes Care·Carolina Ochoa-RosalesTaulant Muka
Mar 11, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jesper B LundQihua Tan
Apr 4, 2020·Journal of Developmental Origins of Health and Disease·Shino Nishizawa-JotakiChisato Mori
Nov 20, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Kumaraswamy Naidu ChitralaMichele K Evans
Nov 30, 2019·Bioinformatics·Zhe CuiHéctor Corrada Bravo
Apr 9, 2020·Biomolecules·Elena Sánchez-LuisJavier De Las Rivas
Mar 28, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Miri CarmelAbraham Weizman
Apr 21, 2020·Journal of the American Heart Association·Kenneth WestermanJosé M Ordovás
Oct 2, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kentaro OkiGregory D Cartee
Feb 26, 2016·Statistical Applications in Genetics and Molecular Biology·Xiaoqing Yu, Shuying Sun
Jan 30, 2020·American Journal of Respiratory and Critical Care Medicine·Jarrett D MorrowDawn L DeMeo
Nov 11, 2016·PloS One·Andrea BurriFrances M K Williams
Sep 9, 2017·Oncotarget·Aurélie HautefortFrédéric Perros
May 13, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Ricky JoshiManel Esteller
Sep 3, 2016·Oncotarget·Smrithi RajendiranJamboor K Vishwanatha
Jan 5, 2020·Clinical Epigenetics·Ting Ting WangWilliam M Grady
Jun 1, 2020·Human Reproduction·K W OlsenM L Grøndahl
Jun 4, 2020·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Morten Muhlig NielsenClaus Højbjerg Gravholt
Jun 4, 2020·Autism Research : Official Journal of the International Society for Autism Research·Sofia StathopoulosColleen O'Ryan
Jun 13, 2019·Nature Communications·Darina CzamaraElisabeth B Binder
Jun 22, 2019·BMC Psychiatry·Yukako NakamuraNorio Ozaki
Jul 4, 2020·The Laryngoscope·Stephen S SchoeffNathan V Welham
Jun 26, 2020·Bioscience Reports·Pashupati P MishraTerho Lehtimäki
Jul 3, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Stephanie ShiauAndrea A Baccarelli
Jul 22, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Parvaneh EbrahimiKristina E Akesson
Jul 31, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christina A MarkunasDana B Hancock
Aug 20, 2019·Aging·Ake T LuSteve Horvath
Jul 20, 2019·Aging·Eric S KimLaura D Kubzansky
Nov 4, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Shuai LiJohn L Hopper
Sep 22, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Erfan Aref-EshghiBekim Sadikovic
Aug 25, 2019·Clinical Epigenetics·Meher Preethi BoorgulaKathleen C Barnes
Jul 25, 2020·The Journal of Clinical Endocrinology and Metabolism·Amit TiroshElectron Kebebew
Sep 2, 2020·Epigenomics·Brian Z HuangZuo-Feng Zhang
Sep 15, 2020·JAMA Network Open·Amy L ProskovecTony W Wilson
Sep 27, 2019·Nature Communications·Ana S Guerreiro StucklinCynthia Hawkins
Oct 1, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Chris McKennanCarole Ober
Apr 1, 2017·Clinical Epigenetics·Larissa HaertleThomas Haaf
Nov 24, 2016·BMC Bioinformatics·Leonie WeinholdMatthias Schmid
Dec 13, 2016·JCI Insight·Jessie Nicodemus-JohnsonCarole Ober
Sep 9, 2016·Breast Cancer Research and Treatment·Ee Ming WongMelissa C Southey
Dec 23, 2016·Statistics in Biosciences·Zhaohui S QinShili Lin
Jun 3, 2017·Human Reproduction·Nady El HajjThomas Haaf
Jun 6, 2017·Oncogene·Enrique VidalManel Esteller
Jul 12, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Andrew RatanatharathornA K Smith
Aug 18, 2017·Scientific Reports·Shuai LiJohn L Hopper
Jan 10, 2018·Genome Biology·Timothy E Van BaakRobert A Waterland
May 4, 2018·Clinical Epigenetics·Kristin M JungeIrina Lehmann
Jun 27, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Xin ZhouXiaodong Cai
Jul 14, 2018·F1000Research·Kevin Rue-AlbrechtAaron T L Lun