PMID: 15376768Sep 21, 2004Paper

Mini extracorporeal circuit for coronary artery bypass grafting: initial clinical and biochemical results: a comparison with conventional and off-pump coronary artery bypass grafts concerning global oxidative stress and alveolar function

Perfusion
Wim Jan P van BovenLeon P Aarts

Abstract

The new concept of mini-extracorporeal circulation (MECC) for coronary artery bypass grafts (MCABG) consists of minimal priming volume, a heparin-coated closed circuit, a centrifugal pump, active drainage, blood cardioplegia and a cell-saving device. The potential organ protective effect of this technique during CABG is unknown. Initial clinical outcomes, oxidative stress, alveolar shunting and need for blood transfusion were investigated for MCABG patients. Sub-sets of these data were compared to outcomes of matched groups of patients operated conventionally (CCABG) and off-pump (OPCAB). Data of 184 patients were gathered and analysed from a prospective observational database system. This database consists of the initial experience with the first 114 MCABG operations. Of these, the clinical outcome was investigated. In a subset of 60 MCABGs, need for transfusion was monitored and compared to 60 CCABGs. Serum concentrations of malondialdehyde (MDA), allantoin/urate ratios, shunt fractions and lung epithelium-specific proteins (CC16) were measured as biomarkers of damage during MCABG, CCABG and OPCAB (n =30). Patient groups were similar concerning age, risk and number of distal anastomoses. Clinical outcomes are shown for MCABGs...Continue Reading

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Citations

Jan 21, 2009·Interactive Cardiovascular and Thoracic Surgery·Anastasia AlevizouJames David Park
Aug 13, 2009·Interactive Cardiovascular and Thoracic Surgery·Gerald F V PandayHarald Hausmann
Oct 27, 2007·Journal of Cardiothoracic Surgery·Kelvin LauNeil Moat
Jan 27, 2010·Mediators of Inflammation·Hunaid A VohraSunil K Ohri
Feb 28, 2015·Oxidative Medicine and Cellular Longevity·Mustafa ZakkarGianni D Angelini
Jul 9, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Leanne HarlingThanos Athanasiou
Nov 18, 2015·Oxidative Medicine and Cellular Longevity·Emad Al JaalyGianni D Angelini
Apr 14, 2015·Disease Markers·Gerwin Erik Engels, Willem van Oeveren
Sep 30, 2014·The International Journal of Artificial Organs·Gerwin E EngelsGiuseppe Faggian
Jul 22, 2008·Artificial Organs·Antoine P SimonsJos G Maessen
Nov 9, 2007·Orvosi hetilap·László GöbölösLajos Papp
Jan 20, 2017·Oxidative Medicine and Cellular Longevity·Fevzi Sarper TürkerMine Erışır
Oct 1, 2008·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Wim-Jan P van BovenLeon P Aarts
Jan 24, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christian A SkrabalAndreas Liebold
Apr 29, 2016·Oxidative Medicine and Cellular Longevity·Daniel Fudulu, Gianni Angelini
Jan 26, 2006·The Journal of Thoracic and Cardiovascular Surgery·A LieboldG Steinhoff

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