Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?

European Journal of Immunology
Britta Engelhardt, Hartwig Wolburg

Abstract

Leukocyte adhesion to the endothelial cells lining the vessel wall and the subsequent migration of the leukocytes into the underlying tissue are key elements of both innate and adaptive immunity. Leukocyte extravasation is generally believed to take place through small gaps at intercellular endothelial cell junctions -- the paracellular route. This view has, however, been repeatedly challenged by morphological studies demonstrating leukocyte migration through the endothelial cells themselves -- the transcellular pathway. On the basis of the current experimental evidence, we propose consideration that both pathways are equally possible for a leukocyte's journey from the apical surface of the endothelium to its basal side.

References

May 1, 1975·The American Journal of Anatomy·A G Farr, P P De Bruyn
Jan 1, 1991·Brain Pathology·H WekerleR Meyermann
Aug 1, 1993·The Journal of Experimental Medicine·W A MullerD M Phillips
Apr 4, 1998·The Journal of Experimental Medicine·D FengA M Dvorak
Jun 11, 1999·Advances in Immunology·E C ButcherM Briskin
Aug 18, 1999·Proceedings of the National Academy of Sciences of the United States of America·M CoradaE Dejana
Jan 19, 2000·The EMBO Journal·H DefacqueG Griffiths
Feb 26, 2000·Cellular and Molecular Neurobiology·U Kniesel, H Wolburg
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S K ShawF W Luscinskas
Jan 29, 2002·Nature Immunology·Alan R SchenkelWilliam A Muller
Apr 30, 2002·Seminars in Immunology·Francis W LuscinskasSunil K Shaw
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul W ThompsonAnne J Ridley
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·John GreenwoodPeter Adamson
Sep 5, 2003·Cell and Tissue Research·Caroline Johnson-Léger, Beat A Imhof
Jul 1, 1956·British Journal of Haematology·J G HUMBLER J PULVERTAFT
Jul 1, 1961·The Journal of Pathology and Bacteriology·H W FLOREY, L H GRANT
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J L GOWANS, E J KNIGHT
Jan 14, 1964·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·V T MARCHESI, J L GOWANS
Dec 1, 1961·The Australian Journal of Experimental Biology and Medical Science·J V HURLEY, N XEROS
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher V CarmanTimothy A Springer
Dec 6, 2003·Journal of Cell Science·Klaus EbnetDietmar Vestweber
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Elisabetta Dejana
Jul 29, 2004·Blood·Gabriele BixelDietmar Vestweber

❮ Previous
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Citations

Mar 18, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kenji OkiMinoru Sasano
Dec 2, 2005·Analytical and Bioanalytical Chemistry·Bernd P MöhrleGünter Gauglitz
Jul 16, 2010·Analytical and Bioanalytical Chemistry·Laura IsacChristoph Riethmuller
Jul 18, 2008·Cell and Tissue Research·Hartwig WolburgPetra Fallier-Becker
Apr 8, 2009·Cell and Tissue Research·J B Dietrich
Oct 7, 2010·International Journal of Clinical Oncology·Nobuyoshi Hiraoka
Jan 9, 2008·Cancer Metastasis Reviews·Isaac P Witz
Jul 11, 2006·Nature Biotechnology·Roger G FahmyLevon M Khachigian
Feb 2, 2006·Nature Cell Biology·Elisabetta Dejana
Jan 24, 2006·Nature Cell Biology·Mikko NieminenSirpa Jalkanen
Jan 22, 2008·Nature Immunology·Boris P-L Lee, Beat A Imhof
Aug 25, 2007·Nature Reviews. Immunology·Klaus LeySussan Nourshargh
May 9, 2009·Nature Reviews. Immunology·Betty DiamondBruce T Volpe
Sep 12, 2008·Nature Reviews. Molecular Cell Biology·Michael Overholtzer, Joan S Brugge
Jul 16, 2008·The Journal of Experimental Medicine·Götz R A EhrhardtMax D Cooper
Sep 24, 2008·Antioxidants & Redox Signaling·Arshad Rahman, Fabeha Fazal
Jan 14, 2010·Cardiovascular Research·Mar Fernandez-BorjaPeter L Hordijk
Aug 28, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H HalleviE Paran
Nov 21, 2012·Epilepsia·N Joan Abbott, Alon Friedman
Jan 13, 2009·Clinical Microbiology Reviews·Julien Santi-RoccaNancy Guillén
Nov 11, 2009·Fiziologiia cheloveka·Iu A Vlasov, S M Smirnov
Feb 9, 2012·Clinical & Developmental Immunology·Theodore S JohnsonBernard L Maria
Jan 1, 2008·Transfusion Medicine and Hemotherapy : Offizielles Organ Der Deutschen Gesellschaft Fur̈ Transfusionsmedizin Und Immunham̈atologie·Britta Engelhardt
Dec 3, 2011·The Journal of Clinical Investigation·Ken CoppietersMatthias von Herrath
May 8, 2009·Blood·Johannes KeuschniggSirpa Jalkanen
Dec 6, 2008·Cell Communication and Signaling : CCS·Carina Strell, Frank Entschladen
Jan 12, 2013·Fluids and Barriers of the CNS·Tobias TenenbaumHorst Schroten
Nov 13, 2012·Fluids and Barriers of the CNS·Anny-Claude LuissintPierre-Olivier Couraud
Jun 10, 2010·Journal of Cell Science·Konstantin StoletovRichard Klemke
Apr 13, 2012·PloS One·Hartwig WolburgMichael Duszenko
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Erika S Wittchen
Jun 2, 2009·Frontiers in Bioscience (Landmark Edition)·Peter T Sage, Christopher V Carman

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