Miniature intracardiac assist device provides more effective cardiac unloading and circulatory support during severe left heart failure than intraaortic balloon pumping

Chest
Koen ReesinkJos Maessen

Abstract

Hemodynamic assistance with a miniature intracardiac pump may fill the treatment gap between use of an intraaortic balloon pump (IABP) and the current, more invasive ventricular assist devices. The objective of this study was to compare the hemodynamic efficacy of a miniature intracardiac pump device with that of IABP. Reversible acute mitral regurgitation (AMR) was induced in eight calves by stenting the mitral valve using a vena cava filter. Full and partial AMR assist were compared with maximum IABP support in each animal. In full-support mode, both assist systems increased cardiac output (miniature intracardiac pump, 13% [p < 0.05]; IABP, 3% [p < 0.05]), mean aortic pressure (miniature intracardiac pump, 13% [p < 0.05]; IABP, 8% [p < 0.05]), carotid artery flow (miniature intracardiac pump, 29% [p < 0.05]; IABP, 5% [difference not significant]), and coronary blood flow (miniature intracardiac pump, 25% [difference not significant]; IABP, 34% [p < 0.05]). Again in full-support mode, both systems reduced left atrial pressure (miniature intracardiac pump, 2.4 mm Hg [p < 0.05]; IABP, 0.7 mm Hg [p < 0.05]), peak left ventricular (LV) pressure (miniature intracardiac pump, 13% [p < 0.05]; IABP, 5% [p < 0.05]), and external LV wor...Continue Reading

Associated Clinical Trials

References

Apr 1, 1979·The American Journal of Cardiology·C YoranE H Sonnenblick
Feb 1, 1983·The American Journal of Cardiology·R A NishimuraA J Tajik
Oct 1, 1995·The Annals of Thoracic Surgery·U LönnH Casimir-Ahn
Oct 1, 1996·The Annals of Thoracic Surgery·M M AmirhamzehH M Spotnitz
Apr 1, 1997·The Journal of Thoracic and Cardiovascular Surgery·D F TorchianaW G Austen
Apr 15, 1997·The American Journal of Cardiology·V G van OmmenH J Wellens
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·P Hornick, K Taylor
Dec 11, 1999·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·J D MarksD B Olsen
Aug 5, 2000·Perfusion·H M Reul, M Akdis
Feb 13, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A L DekkerF H van der Veen
Jun 14, 2001·Artificial Organs·R AutschbachF W Mohr
Jul 10, 2002·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·B MeynsE Fischer

❮ Previous
Next ❯

Citations

Jul 16, 2008·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Christian JungHans-Reiner Figulla
Nov 11, 2010·Current Treatment Options in Cardiovascular Medicine·Chetan B PatelJoseph G Rogers
Aug 2, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Luc G MorrisLisa A Liberatore
Apr 24, 2012·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Roberto J CubedduIgor F Palacios
Feb 14, 2014·Current Treatment Options in Cardiovascular Medicine·Jason Hatch, Dmitri Baklanov
Dec 26, 2009·Journal of Cardiovascular Medicine·Alessandro SciahbasiErnesto Lioy
Jan 24, 2009·Scandinavian Cardiovascular Journal : SCJ·Hans GranfeldtHenrik Ahn
Dec 8, 2009·Cardiology Clinics·Kunal Sarkar, Annapoorna S Kini
Oct 22, 2008·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Mario ArietiFlavio Ribichini
Apr 26, 2008·Heart, Lung & Circulation·Michael Rossiter-ThorntonMichael K Wilson
Sep 27, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Mar 21, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel Burkhoff, Srihari S Naidu
Nov 27, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Maurice RemmelinkJan Baan
Jun 22, 2010·The Laryngoscope·Benjamin R RomanLuc G T Morris
May 23, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrea GarattiEttore Vitali
Aug 24, 2010·Perfusion·Kevin E Griffith, Eric Jenkins
Sep 28, 2017·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Jacob ElietPascal H Colson
Mar 9, 2018·Journal of the American Heart Association·Shin WatanabeKiyotake Ishikawa
Jul 20, 2005·Circulation·Donna Mancini, Daniel Burkhoff
Apr 7, 2007·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Dongfang WangWillem J Kolff
Oct 23, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Douglas L JenningsAkshay Khandelwal
Jun 20, 2020·Artificial Organs·Daniël I M van DortGuillaume S C Geuzebroek
Feb 20, 2019·Bioengineering·Jooli Han, Dennis R Trumble
Jan 13, 2012·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Guang-Wei ZhangChun Wang
Mar 2, 2021·Journal of Cardiothoracic and Vascular Anesthesia·P MeaniF Pappalardo
May 5, 2021·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Yu HohriHitoshi Yaku

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.