Miniature multichannel preamplifier for extracellular recordings of single unit activity in freely moving and swimming small animals

Journal of Neuroscience Methods
Victor A Korshunov

Abstract

The design of a miniature multichannel preamplifier for extracellular recordings of single unit activity in freely moving and swimming small animals is presented. The advantages of this design include perfect protection of the critical components and electric contacts from water. Thus, neuronal activity and EEG may be recorded differentially in any kinds of behavioral tasks including swimming in Morris water maze. Recordings are stable even if an animal is diving and swimming under the water surface. The reusable dismountable base can adopt different types of chronically implanted fine wire electrodes and movable arrays. Electrodes may be implanted to any desired depth. The assembly weight is less than 240 mg. Thus, the construction is light enough even for mice. This work is the first successful attempt for multichannel recording of neuronal activity in mice performing spatial task in Morris water maze.

References

May 1, 1984·Journal of Neuroscience Methods·R Morris
Apr 4, 2001·The European Journal of Neuroscience·S A HollupE I Moser
Jun 1, 2002·Science·Kazu NakazawaSusumu Tonegawa
Apr 22, 2004·Nature Reviews. Neuroscience·Kazu NakazawaSusumu Tonegawa
Jan 18, 2005·Journal of Neuroscience Methods·R L RennakerA M Sloan
Aug 3, 2007·Journal of Neuroscience Methods·Victor A Korshunov, Robert G Averkin

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Citations

Feb 2, 2016·PloS One·Richard C PinnellUlrich G Hofmann
May 31, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rami HamatiPierre Blier

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