Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample

Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Migaku KawaguchiHiroyuki Nakazawa

Abstract

The determination of benzophenones (BPs) in human urine sample by miniaturized hollow fiber assisted liquid-phase microextraction (HF-LPME) and gas chromatography-mass spectrometry (GC-MS) is described. As analytes, BP, its metabolites benzhydrol (BP-OH) and 2-hydroxybenzophenone (2OH-BP), and its derivatives 2-hydroxy-4-methoxybenzophenone (BP-3) and 2-hydroxy-4-methoxy-4'-methylbenzophenone (BP-10) were selected. The detection limit and the quantification limit of BPs in human urine sample are 5-10 and 20-50 pg mL(-1), respectively. The calibration curve for BPs is linear with correlation coefficient higher than 0.99 in the range of 0.02-10 or 0.05-10 ng mL(-1). The average recoveries of BPs in human urine samples spiked with 0.5 and 5 ng mL(-1) BPs are 89.8-100.2% (RSD: 2.5-9.3%) and 89.3-99.9% (RSD: 2.9-3.7%), respectively. Ten human urine samples were analyzed using the present method. BP-OH and BP-3 were detected in all the samples within the range of 0.24-5.91 and 0.43-5.17 ng mL(-1), respectively. This simple, sensitive, and selective analytical method was successfully applied to the determination of trace amounts of BPs in human urine samples.

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Citations

Sep 4, 2009·Analytical and Bioanalytical Chemistry·Hiroyuki Kataoka
Nov 21, 2014·Bioanalysis·Maryam RezazadehShahram Seidi
Dec 3, 2016·Journal of Chromatographic Science·Ali Mohamed Ali AlsharifAbubakar Lawal
Mar 4, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Hiroyuki Nakazawa
Aug 12, 2009·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Rie ItoHiroyuki Nakazawa
Feb 14, 2020·Journal of Exposure Science & Environmental Epidemiology·Hanne FrederiksenAnna-Maria Andersson
Apr 22, 2019·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Marcello LocatelliAbuzar Kabir
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Izabela Narloch, Grażyna Wejnerowska

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