Miniaturized optical neuroimaging in unrestrained animals

NeuroImage
Hang YuArvind P Pathak

Abstract

The confluence of technological advances in optics, miniaturized electronic components and the availability of ever increasing and affordable computational power have ushered in a new era in functional neuroimaging, namely, an era in which neuroimaging of cortical function in unrestrained and unanesthetized rodents has become a reality. Traditional optical neuroimaging required animals to be anesthetized and restrained. This greatly limited the kinds of experiments that could be performed in vivo. Now one can assess blood flow and oxygenation changes resulting from functional activity and image functional response in disease models such as stroke and seizure, and even conduct long-term imaging of tumor physiology, all without the confounding effects of anesthetics or animal restraints. These advances are shedding new light on mammalian brain organization and function, and helping to elucidate loss of this organization or 'dysfunction' in a wide array of central nervous system disease models. In this review, we highlight recent advances in the fabrication, characterization and application of miniaturized head-mounted optical neuroimaging systems pioneered by innovative investigators from a wide array of disciplines. We broadly c...Continue Reading

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Citations

Sep 12, 2015·IEEE Transactions on Biomedical Circuits and Systems·Xiao ZhangKartikeya Murari
Jan 31, 2018·Proceedings of the National Academy of Sciences of the United States of America·Luyao LuJohn A Rogers
Jan 11, 2019·Nature Communications·Janaka SenarathnaArvind P Pathak
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Oct 6, 2020·Biomedical Optics Express·Linhui YuKartikeya Murari

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