Minibeam therapy with protons and light ions: physical feasibility and potential to reduce radiation side effects and to facilitate hypofractionation

International Journal of Radiation Oncology, Biology, Physics
F A DilmanianSunil Krishnan

Abstract

Despite several advantages of proton therapy over megavoltage x-ray therapy, its lack of proximal tissue sparing is a concern. The method presented here adds proximal tissue sparing to protons and light ions by turning their uniform incident beams into arrays of parallel, small, or thin (0.3-mm) pencil or planar minibeams, which are known to spare tissues. As these minibeams penetrate the tissues, they gradually broaden and merge with each other to produce a solid beam. Broadening of 0.3-mm-diameter, 109-MeV proton pencil minibeams was measured using a stack of radiochromic films with plastic spacers. Monte Carlo simulations were used to evaluate the broadening in water of minibeams of protons and several light ions and the dose from neutron generated by collimator. A central parameter was tissue depth, where the beam full width at half maximum (FWHM) reached 0.7 mm, beyond which tissue sparing decreases. This depth was 22 mm for 109-MeV protons in a film stack. It was also found by simulations in water to be 23.5 mm for 109 MeV proton pencil minibeams and 26 mm for 116 MeV proton planar minibeams. For light ions, all with 10 cm range in water, that depth increased with particle size; specifically it was 51 mm for Li-7 ions. Th...Continue Reading

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Citations

Dec 23, 2015·International Journal of Radiation Oncology, Biology, Physics·Stefanie GirstThomas E Schmid
Dec 4, 2015·Medical Physics·C PeucelleY Prezado
Dec 10, 2015·Frontiers in Oncology·F Avraham DilmanianSunil Krishnan
Nov 20, 2015·International Journal of Radiation Oncology, Biology, Physics·F Avraham DilmanianSunil Krishnan
Feb 27, 2017·Medical Physics·Wilfredo GonzálezYolanda Prezado
Jan 11, 2018·Medical Physics·Toshiro TsubouchiAlbert Siegbahn
Apr 11, 2018·Medical Physics·W González, Y Prezado
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Sep 8, 2017·Medical Physics·Matthias SammerGünther Dollinger
Oct 26, 2018·The British Journal of Radiology·Juergen MeyerYolanda Prezado
Jan 17, 2020·The British Journal of Radiology·F Avraham DilmanianSunil Krishnan
Jun 8, 2019·Medical Physics·Tim SchneiderYolanda Prezado
Aug 9, 2016·Physics in Medicine and Biology·F MarsolatA Mazal
Oct 21, 2017·Physics in Medicine and Biology·Juergen MeyerGeorge Sandison
Jan 1, 2016·Technology in Cancer Research & Treatment·Thomas HenryAlbert Siegbahn
Nov 9, 2018·Scientific Reports·Yolanda PrezadoFrederic Pouzoulet
Jul 1, 2016·Physics in Medicine and Biology·Eunsin LeeGeorge Sandison
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