Minimal adenocarcinoma in prostate needle biopsy tissue

American Journal of Clinical Pathology
P Thorson, P A Humphrey

Abstract

One of the major diagnostic challenges in prostate needle biopsy interpretation is definitive establishment of a malignant diagnosis based on a minimal or limited amount of carcinoma in needle biopsy tissue. Major and minor diagnostic criteria should be used for interpretation of small foci of carcinoma. The constellation of findings and a combination of the major and minor diagnostic criteria permit a definitive diagnosis of focal adenocarcinoma. The differential diagnosis of minimal prostatic adenocarcinoma in needle biopsy tissue is broad and includes many benign lesions. The benign entities most likelty to be misdiagnosed as minimal prostatic adenocarcinoma are atypical adenomatous hyperplasia (adenosis) and atrophy. High-grade prostatic intraepithelial neoplasia and a descriptive diagnosis of focal glandular atypia or atypical small acinar proliferation also should be considered before diagnosing minimal adenocarcinoma. The most valuable adjunctive study for the diagnosis of minimal adenocarcinoma is immunohistochemistry using antibody 34 beta E12, reactive against basal cell-specific high-molecular-weight cytokeratins. Most cases can be diagnosed based on H&E-stained sections without this immunostain. Most minimal carcino...Continue Reading

References

Oct 1, 1991·Human Pathology·J E McNealT A Stamey
Mar 1, 1986·The Journal of Urology·T L McIntire, D A Franzini
May 1, 1989·The American Journal of Surgical Pathology·L Hedrick, J I Epstein
Dec 1, 1983·American Journal of Clinical Pathology·K R ClearyA G Ayala
Feb 2, 1994·JAMA : the Journal of the American Medical Association·J I EpsteinC B Brendler
Sep 1, 1995·The American Journal of Surgical Pathology·J C Cheville, D G Bostwick
Aug 1, 1995·The American Journal of Surgical Pathology·J I EpsteinT M Wheeler
Mar 1, 1993·The American Journal of Surgical Pathology·D J Grignon, F P O'Malley
Jun 1, 1993·Human Pathology·C E Kramer, J I Epstein
Jul 1, 1995·The American Journal of Surgical Pathology·P B Gaudin, J I Epstein
Aug 1, 1994·The American Journal of Surgical Pathology·D G Bostwick
Dec 1, 1995·American Journal of Clinical Pathology·R H Young
Jul 1, 1996·The American Journal of Surgical Pathology·J I EpsteinF Sanfilippo
May 1, 1996·British Journal of Urology·V RaveryL Boccon-Gibod
Jan 1, 1997·American Journal of Clinical Pathology·A A Renshaw
Mar 1, 1997·The American Journal of Surgical Pathology·S J Cina, J I Epstein
May 1, 1997·The American Journal of Surgical Pathology·D M SteinbergJ I Epstein
Jun 1, 1997·The American Journal of Surgical Pathology·J M HenneberryJ I Epstein
Aug 1, 1997·The American Journal of Surgical Pathology·A J EganD G Bostwick
Dec 31, 1997·The American Journal of Surgical Pathology·K A IczkowskiD G Bostwick
Apr 16, 1998·American Journal of Clinical Pathology·A O Reyes, P A Humphrey
Apr 16, 1998·The American Journal of Surgical Pathology·J R OppenheimerJ I Epstein
Apr 16, 1998·The American Journal of Surgical Pathology·R C AntonT M Wheeler
Apr 16, 1998·The Prostate·M H WeinsteinJ I Epstein
May 22, 1998·Human Pathology·A PacelliD G Bostwick
Sep 16, 1998·The American Journal of Surgical Pathology·K M RuskaJ I Epstein

❮ Previous
Next ❯

Citations

Aug 19, 2014·Human Pathology·Vadim KhachaturovDavid E Burstein
Mar 1, 2003·Journal of Clinical Pathology·X LeroyB Gosselin
Apr 12, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Omar Hameed, Peter A Humphrey
Aug 25, 2004·American Journal of Clinical Pathology·Zhong JiangXiming J Yang
Aug 19, 2011·Annals of Diagnostic Pathology·Farhat Rashid, Anwar Ul Haque
Dec 1, 2008·Surgical Pathology Clinics·Ming Zhou, Cristina Magi-Galluzzi
Jan 11, 2007·American Journal of Clinical Pathology·Victor WengLeong NgPuay Hoon Tan
Sep 9, 2008·Annals of Diagnostic Pathology·Julian Arista-NasrJorge Albores-Saavedra
Mar 24, 2007·BJU International·Sarah C FluryDan Theodorescu
Jan 4, 2012·Histopathology·Glen Kristiansen
Jan 30, 2009·Medical Physics·Jeffrey BaxAaron Fenster
May 3, 2005·International Journal of Surgical Pathology·Antonio Lopez-BeltranDavid G Bostwick
Jul 15, 2017·International Journal of Surgical Pathology·Julian Arista-NasrJorge Albores-Saavedra
Feb 21, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Wael A Sakr
Dec 29, 2007·The American Journal of Surgical Pathology·Christopher G PrzybycinRajal B Shah
Jun 17, 2005·The American Journal of Surgical Pathology·Samson W Fine, Jonathan I Epstein
Jan 4, 2018·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Cristina Magi-Galluzzi
Oct 27, 2004·Advances in Anatomic Pathology·Zhong Jiang, Bruce A Woda
Aug 23, 2017·Critical Reviews in Clinical Laboratory Sciences·Francesca SanguedolceLuigi Cormio
Apr 3, 2020·International Journal of Surgical Pathology·Julian Arista-NasrJorge Albores-Saavedra
Apr 17, 2004·Archives of Pathology & Laboratory Medicine·Oluwole FadareM Rajan Mariappan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
J I Epstein
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
John R Srigley
© 2021 Meta ULC. All rights reserved