Minimal antibiotic concentrations of aminoglycosides and beta-lactam antibiotics for some gram-negative bacilli and gram-positive cocci

The Journal of Infectious Diseases
V Lorian, C C De Freitas

Abstract

The minimal antibiotic concentration (MAC) is the lowest concentration of an antibacterial agent that produces a decrease of 1 log in the number of organisms/ml as compared with a control culture in drug-free medium. Various gram-negative bacilli and gram-positive cocci were grown in the presence of amikacin, gentamicin, tobramycin, ampicillin, amoxicillin, oxacillin, carbenicillin, ticarcillin, and cefamandole at concentrations varying from eight times the minimal inhibitory concentration (MIC) to 1/128 of the MIC. Colony forming units (cfu) were counted, the MIC was determined, and the MIC:MAC ratio, which indicates the magnitude of the effective range, was calculated. The MIC:MAC ratio appears to be characteristic for a given species and antibiotic. There is no relation between the MICs and the MIC:MAC ratios. The highest ratios were given by Proteus mirabilis with aminoglycosides (MIC:MAC mean, 29.2 with tobramycin), and the lowest ratios were given with beta-lactam antibiotics by Pseudomonas aeruginosa and Streptococcus faecalis (MIC:MAC means, 2.1 with carbenicillin and cefamandole, respectively).

Citations

Jul 1, 1982·Antimicrobial Agents and Chemotherapy·L SchrireH J Koornhof
Dec 1, 1982·Antimicrobial Agents and Chemotherapy·S B RedjebV Lorian
Apr 1, 1989·Antimicrobial Agents and Chemotherapy·D E CorpetF Corpet
Jan 1, 1986·Scandinavian Journal of Infectious Diseases·K RoosS E Holm
Jan 1, 1987·Scandinavian Journal of Infectious Diseases·E Grahn, S E Holm
Jan 1, 1984·Scandinavian Journal of Infectious Diseases. Supplementum
Jan 1, 1982·Critical Reviews in Microbiology·B A Atkinson, L Amaral
Jul 1, 1983·Drug Intelligence & Clinical Pharmacy·S A Hunt, M J Rybak
Apr 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section B, Microbiology·A R OgaardB P Berdal

Related Concepts

Aminoglycosides
Bacteriocidal Agents
Dose-Response Relationship, Drug
Alkalescens-Dispar Group
Klebsiella rhinoscleromatis
Fungus Drug Sensitivity Tests
Proteus mirabilis
Pseudomonas aeruginosa
Staphylococcus aureus
Enterococcus faecalis

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

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