Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Geoffrey W McCaughanAustralian and New Zealand Liver Transplant Study Group

Abstract

Although 1-year survival rates following liver transplantation over the last 20 years may have improved, there is doubt about improvement in long-term survival. We examined survival with and without initial 12-month mortality in adult liver transplant recipients over a 20-year period. Patient and allograft survival for 3 different time periods was compared: 1986-1994 (group 1, n = 547), 1995-2000 (group 2, n = 735), and 2000-2005 (group 3, n = 749). After this, all deaths in the first 12 months of each group were removed. Patient and allograft survival was then once again compared across the 3 groups. There was significant improvement in both patient and allograft survival across the 20-year period (P < 0.001). Overall patient and allograft survival improved in non-hepatitis C virus (HCV) patients but not in HCV patients. A similar comparison with deaths in the first year removed, however, showed no difference in patient survival (P = 0.07) and only a marginal improvement in allograft survival (P = 0.048) between the 3 time periods. When patients were divided into HCV-positive and HCV-negative groups with deaths in the first year removed, there was, however, improved patient and allograft survival in the HCV-negative group but ...Continue Reading

References

May 1, 1990·Transplantation·J D PirschF D Belzer
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marina BerenguerJoaquín Berenguer
Nov 20, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·René AdamUNKNOWN European Liver Transplant Association
Feb 14, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Herwig-Ulf Meier-KriescheBruce Kaplan
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y FutagawaD W Gjertson
Sep 30, 2006·Gut·K BarberUNKNOWN UK Transplant Liver Advisory Group

❮ Previous
Next ❯

Citations

Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anoma Nellore, Jay A Fishman
Oct 16, 2015·Nature Reviews. Gastroenterology & Hepatology·Kymberly D Watt
Jun 19, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Suzanne E MahadyJacob George
Mar 25, 2011·Clinical Transplantation·Rolland C DicksonJustin H Nguyen
Dec 15, 2010·Hepatitis Research and Treatment·Yasuhiko SugawaraNorihiro Kokudo
Mar 31, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Geoffrey W McCaughan, Stephen R Munn
Jan 1, 2017·Clinical Transplantation·Kim E DanielMichael R Lucey
Oct 9, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jess HowellPaul Gow

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
U KhettryFredric D Gordon
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R F Liermann GarciaJ M Neuberger
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R H WiesnerK Detre
© 2021 Meta ULC. All rights reserved