Sep 1, 1992

Minimal coronary stenoses and left ventricular blood flow during CPR

Annals of Emergency Medicine
K B Kern, G A Ewy


To assess the effect of a 33% coronary stenosis on myocardial blood flow during normal sinus rhythm and CPR. Prospective, before and after cardiac arrest and CPR; before and after creation of a 33% stenosis. The University of Arizona Resuscitation Research Laboratory. Ten domestic closed-chest swine with patent coronary stenoses. A Teflon cylinder was placed in the mid-left anterior descending coronary artery to create a 33% stenosis. Myocardial blood flow was measured with colored microspheres both proximal and distal to the stenosis during normal sinus rhythm and during CPR. During normal sinus rhythm, the stenosis did not alter the amount of myocardial blood flow distribution or quantity. Proximal to the stenosis the endocardial/epicardial flow ratio was 1.49 +/- 0.33, and distal to the stenosis it was 1.50 +/- 0.50. Likewise, during normal sinus rhythm, blood flow proximal and distal to the stenosis did not differ for either the epicardium (79 +/- 9 versus 66 +/- 13 mL/min/100 g) or the endocardium (111 +/- 27 versus 83 +/- 19 mL/min/100 g). However, the distribution of myocardial blood flow was markedly altered during CPR. The resultant endocardial/epicardial flow ratios were significantly less than during normal sinus rhy...Continue Reading

Mentioned in this Paper

Coronary Circulation
Blood Flow Velocity
Basic Cardiac Life Support
Left Ventricular Function
Sinus Node Artery
Family suidae
Farm Animals

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