Minimal enteral feeding reduces the risk of sepsis in feed-intolerant very low birth weight newborns

Acta Paediatrica
Gianluca TerrinConcetta Cascioli

Abstract

To evaluate the efficacy and safety of minimal enteral feeding (MEF) nutritional practice in feed-intolerant very low birth weight (VLBW) infants. A retrospective design using data reported in the clinical charts of VLBW newborns consecutively observed in neonatal intensive care units (NICU) that presents feed intolerance. During the study period, two feeding strategies were adopted: total parenteral nutrition (PN) (group 1) or PN plus MEF (group 2), for at least 24 h. Primary outcome was the time to reach full enteral feeding; secondary outcomes were the occurrence of sepsis, the time to regain birth weight, the length of hospitalization, the occurrence of necrotizing enterocolitis (NEC) Bell stage >II and death. In total, 102 newborns were evaluated: 51 in group 1, and 51 in group 2. Neonates in group 2 achieved full enteral nutrition earlier (8 days, interquartile range [IQR] 5) compared with subjects receiving total PN (11 days, IQR 5, p < 0.001). A reduction of sepsis episodes was observed in group 2 (15.7%) compared with group 1 (33.3%, p = 0.038). Additionally, subjects in group 2 regained their birth weight and were discharged earlier. The occurrence of NEC and death were similar in the two groups. Minimal enteral feedi...Continue Reading

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Citations

Feb 22, 2014·Journal of Pediatric Gastroenterology and Nutrition·Sissel J MoltuAne C Westerberg
Dec 3, 2014·Clinics in Perinatology·Josef Neu
Sep 5, 2014·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Guglielmo SalvatoriAndrea Dotta
Feb 15, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Shehzad HudaArun Pramanik
Feb 19, 2013·Clinics in Perinatology·Manimaran Ramani, Namasivayam Ambalavanan
Dec 12, 2012·Journal of Paediatrics and Child Health·Barbara CormackDavid Tudehope
Mar 24, 2016·BMC Pregnancy and Childbirth·Gianluca TerrinMario De Curtis
Aug 26, 2014·BioMed Research International·Gianluca TerrinMario De Curtis
Oct 22, 2010·JPEN. Journal of Parenteral and Enteral Nutrition·Jessica A Dominguez
Apr 6, 2017·Journal of Pediatric Gastroenterology and Nutrition·Gianluca TerrinMario De Curtis
Mar 16, 2018·Journal of Pediatric Gastroenterology and Nutrition·Elizabeth A BrownellJames I Hagadorn
Mar 20, 2020·BMJ Open Quality·Mitchell KreschColeen Greecher
Dec 23, 2015·Nutrients·Gianluca TerrinMario De Curtis
Sep 29, 2020·Frontiers in Neurology·Gianluca TerrinMario De Curtis
Mar 15, 2019·Current Pediatric Reviews·Capriati Teresa de Ville de Goyet Jean
Jan 16, 2021·Italian Journal of Pediatrics·Gianluca TerrinMario De Curtis
Aug 13, 2021·Acta Paediatrica·Amanda de Havilland, Gopakumar Hariharan

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