Minimal erythema dose after multiple UV exposures depends on pre-exposure skin pigmentation

Photodermatology, Photoimmunology & Photomedicine
M HenriksenHans Christian Wulf

Abstract

Phototherapy consists of multiple ultraviolet (UV) exposures. Most previous studies have focused on erythema following a single UV exposure in fair-skinned persons. Although it is well known that phototherapy lowers the daily UV-threshold dose for erythema in clinical practice, this is insufficiently documented under controlled experimental conditions. The purpose of this study was to quantify the change in the daily threshold for a dose specific erythema grade after 1-4 consecutive daily UV exposures. Forty-nine healthy volunteers (skin type II-V) with varying pigmentation quantified by skin reflectance. Two UV sources were used: a narrowband UVB (Philips TL01) and a Solar Simulator (Solar Light Co.). Just perceptible erythema after 24 h was chosen as the minimal erythema dose (+); besides + and ++ were assessed. We found a positive and significant exponential relationship between skin pigmentation and UV dose to elicit a specific erythema grade on the back after 1-4 UV exposures. After repetitive UV exposures the UV dose had to be lowered more in dark-skinned persons compared with fair-skinned persons to elicit a certain erythema grade. This applied to both UV sources and all erythema grades. In the dark-skinned persons the d...Continue Reading

References

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Citations

Jan 27, 2007·Archives of Dermatological Research·M H Ravnbak, H C Wulf
Jul 23, 2008·Photochemistry and Photobiology·Merve MeinhardtHagen Tronnier
Mar 29, 2012·Cutaneous and Ocular Toxicology·Mi-Na XiaGuo-Biao Fan
Nov 7, 2006·Pigment Cell Research·S Del BinoF Bernerd
Jun 22, 2015·Journal of Photochemistry and Photobiology. B, Biology·Amra OsmancevicAnne-Lene Krogstad
Jan 12, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Pameli DattaHans Christian Wulf
Nov 26, 2010·Photodermatology, Photoimmunology & Photomedicine·Hans Christian WulfMette H Ravnbak
Dec 3, 2010·Journal of Cosmetic Dermatology·Chao YuanPei-lan Wu
Nov 1, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Lindsay R SklarIltefat Hamzavi
Jan 20, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Y TanS Wang
Mar 20, 2020·Photodermatology, Photoimmunology & Photomedicine·June K RobinsonMary Kwasny
Mar 11, 2008·Biomedical Microdevices·Balabhaskar PrabhakarpandianShivshankar Sundaram
Dec 1, 2019·Photodermatology, Photoimmunology & Photomedicine·Giedre BieliauskieneHans Christian Wulf
Dec 17, 2010·Experimental Dermatology·Morten K B BoghHans Christian Wulf

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