Minimal influence of blood flow on interstitial glucose and lactate-normal and insulin-resistant muscle

The American Journal of Physiology
Agneta HolmängPeter Lönnroth

Abstract

To study the regulation of the interstitial glucose concentration in skeletal muscle, nine control subjects and nine older and overweight non-insulin-dependent diabetes mellitus (NIDDM) subjects with extreme insulin resistance were investigated with microdialysis in the medial femoral muscle before and during a euglycemic insulin clamp. After an overnight fast, arterial plasma glucose concentration was 4.9 +/- 0.1 and 8.5 +/- 0.6 mmol/l (P < 0.001), respectively. The arterial-interstitial concentration ([a-i]) differences of glucose and lactate were 0.43 +/- 0.16 (P < 0.05) and -0.13 +/- 0.05 mmol/l, respectively, in normal subjects. In NIDDM subjects, [a-i] differences for glucose and lactate were nonsignificant. Muscle blood flow was similar in controls and NIDDM subjects. During the glucose clamp, the glucose [a-i] differences increased and the lactate [a-i] differences decreased significantly in both groups. The glucose 170 infusion rate was 8.0 +/- 0.77 vs. 3.2 +/- 0.51 mg.kg-1.min-1 (P < 0.001), and blood flow was 9.9 +/- 1.6 vs. 6.7 +/- 0.9 ml.100 g-1.min-1 (P < 0.05) in controls and NIDDM subjects, respectively. These results show that 1) the capillary wall is rate limiting for muscle glucose uptake and lactate release ...Continue Reading

References

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Citations

Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·M SjöstrandP Lönnroth
Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·John M Kinney
Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·P PeltoniemiP Nuutila
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Charles KennergrenPeter Lonnroth
May 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·A E HalsethD H Wasserman
Feb 14, 2002·Journal of Applied Physiology·Agneta HolmängPeter Lönnroth
Apr 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Werner RegittnigThomas R Pieber
Oct 9, 2008·American Journal of Physiology. Endocrinology and Metabolism·David H Wasserman
Nov 8, 2019·The Journal of Physiology·Glenn K McConellErik A Richter

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