PMID: 9183779Jan 1, 1997Paper

Minimal model of food absorption in the gut

Medical Informatics = Médecine Et Informatique
D R Worthington

Abstract

Of the physiological subsystems involved in glucose metabolism, all have now been modelled with continuous-time compartmental models except the gut. To address this omission, three progressively more complex models of the conversion of food by the gut into the rate of appearance of glucose in plasma were identified, using two different sample input foods which were tested on a type 1 diabetic patient. The minimal model that achieved a reasonable match with measured values had one compartment. Two model parameters specific to the food modelled were glycaemic value (grams of glucose per gram of food), and the fractional turnover rate, corresponding to a combination of the gastric emptying time constant and other rate limiting metabolic processes. Parameters specific to the individual were compartmental volumes, specifically for the glucose distribution space. It was only possible to achieve an adequate model prediction with a one compartmental model by explicitly incorporating transport delay into the model. By combining this model with models of insulin production and glucose disposal, the glycaemic response of an identified food may also be predicted for patients with type 2 diabetes mellitus. This predicted responses, along wi...Continue Reading

References

Jan 1, 1991·Canadian Journal of Physiology and Pharmacology·C B Hollenbeck, A M Coulston
Jul 1, 1990·Computer Methods and Programs in Biomedicine·D R Worthington
Aug 18, 1984·Lancet·D J JenkinsG S Wong
Mar 1, 1981·The American Journal of Clinical Nutrition·D J JenkinsD V Goff
Oct 1, 1995·Medical Informatics = Médecine Et Informatique·E D Lehmann, T Deutsch
Oct 1, 1995·Medical Informatics = Médecine Et Informatique·E D Lehmann, T Deutsch
Jan 1, 1997·Medical Informatics = Médecine Et Informatique·D R Worthington

❮ Previous
Next ❯

Citations

Jan 1, 1997·Medical Informatics = Médecine Et Informatique·D R Worthington
May 1, 2008·Journal of Diabetes Science and Technology·Xing-Wei WongGeoffrey M Shaw
Feb 20, 2010·Journal of Diabetes Science and Technology·Malgorzata E WilinskaRoman Hovorka
Jan 1, 1997·Medical Informatics = Médecine Et Informatique·E D Lehmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

© 2021 Meta ULC. All rights reserved