PMID: 2508738Nov 1, 1989Paper

Minimal neuropsychological sequelae following prophylactic treatment of the central nervous system in adult leukaemia and lymphoma

British Journal of Cancer
J TuckerP Patel

Abstract

The potential long-term toxicity of central nervous system prophylaxis (CNS-P) in adult acute lymphoblastic leukaemia (ALL, n = 17) and non-Hodgkin's lymphoma (NHL, n = 7) was investigated in a multidisciplinary study. At least 4 years had elapsed from CNS-P (mean 11.5 years) for all patients. Neurological history and physical examination were unremarkable; minor signs were commoner in older patients (P less than 0.02). Psychometry yielded normal results, but individual verbal IQ generally exceeded performance IQ, with a trend to more marked differences in younger adults (P = 0.06). EEG was scored and differed significantly from that of controls, with a tendency to more marked (but still minor) abnormalities in younger patients (P = 0.06). Brainstem auditory evoked potentials demonstrated significant but generally minor abnormality in 24% of patients. CT brain scan revealed widening of cerebral hemisphere sulci to greater than 3 mm in 38% of patients; cerebral atrophy was commoner in the older group (P less than 0.02) and those with neurological signs (P less than 0.02). MRI brain scans were normal in all patients tested. Thus, following standard CNS-P for ALL at this hospital, there is a 5% primary CNS relapse rate, and only m...Continue Reading

Citations

Apr 29, 2010·Current Hematologic Malignancy Reports·Amber FullmerElias Jabbour
Nov 1, 1992·Cancer·M A AndrykowskiP J Henslee-Downey
Dec 1, 1993·British Journal of Haematology·A Z Rohatiner, T A Lister
Feb 1, 1993·Journal of Learning Disabilities·R T Brown, A Madan-Swain
Jan 9, 2010·Expert Opinion on Emerging Drugs·Amber FullmerElias Jabbour
Jan 24, 2004·Journal of the International Neuropsychological Society : JINS·Cay Anderson-HanleyBruce E Compas

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