Minimal Pleural Effusion in Small Cell Lung Cancer: Proportion, Mechanisms, and Prognostic Effect

Radiology
Jeong-Seon RyuSeung-Sik Hwang

Abstract

To determine the frequency and investigate possible mechanisms and prognostic relevance of minimal (<10-mm thickness) pleural effusion in patients with small cell lung cancer (SCLC). The single-center retrospective study was approved by the institutional review board of the hospital, and informed consent was waived by the patients. A cohort of 360 consecutive patients diagnosed with SCLC by using histologic analysis was enrolled in this study. Based on the status of pleural effusion on chest computed tomographic (CT) scans at diagnosis, patients were classified into three groups: no pleural effusion, minimal pleural effusion, and malignant pleural effusion. Eighteen variables related to patient, environment, stage, and treatment were included in the final model as potential confounders. Minimal pleural effusion was present in 74 patients (20.6%) and malignant pleural effusion in 83 patients (23.0%). Median survival was significantly different in patients with no, minimal, or malignant pleural effusion (median survival, 11.2, 5.93, and 4.83 months, respectively; P < .001, log-rank test). In the fully adjusted final model, patients with minimal pleural effusion had a significantly increased risk of death compared with those with ...Continue Reading

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Citations

Apr 8, 2016·Current Opinion in Pulmonary Medicine·Erin DeBiasi, Jonathan Puchalski
Aug 25, 2019·Medicina·Kristijan SkokAnton Crnjac
Dec 10, 2020·EMBO Molecular Medicine·Julie KoJulien Sage
May 24, 2019·Respiration; International Review of Thoracic Diseases·Samira ShojaeePatrick Nana-Sinkam

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